Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort

Wiegel, Rosalieke E.; Karsten, Maud J. H.; Reijnders, Igna F.; van Rossem, Lenie; Willemsen, Sten P.; Mulders, Annemarie G. M. G. J.; Koning, Anton H. J.; Steegers, Eric A. P.; Danser, A. H. Jan; Steegers-Theunissen, Régine P. M.

doi:10.1186/s12958-021-00843-9

Table 3 Associations between first-trimester maternal RAAS concentrations and trajectories of utero-placental (vascular) development and placental weight

From: Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort

		Model 1		Model 2
		Beta (95% CI)	p-value	Beta (95% CI)	p-value
First-trimester trajectories (n = 151)
PV (∛cm³)	Log [Prorenin (pg/mL)]	-0.04 (-0.19; 0.12)	0.65	-0.14 (-0.33; 0.06)	0.16
PV (∛cm³)	Log [Aldosterone/renin ratio]	0.12 (0.01; 0.22)	0.04*	0.12 (0.01; 0.24)	0.04*
uPVV (∛cm³)	Log [Prorenin (pg/mL)]	-0.08 (-0.27; 0.10)	0.38	-0.23 (-0.44; -0.02)	0.04*
uPVV (∛cm³)	Log [Aldosterone/renin ratio]	0.003 (-0.13; 0.14)	0.96	0.01 (-0.13; 0.14)	0.91
Total pregnancy trajectories (n = 201)
UtA-RI	Log [Prorenin (pg/mL)]	0.04 (0.001; 0.07)	0.04*	0.10 (0.01, 0.20)	0.04*
UtA-RI	Log [Aldosterone/renin ratio]	-0.02 (-0.05; 0.003)	0.08	-0.01 (-0.04; 0.01)	0.27
UtA- PI	Log [Prorenin (pg/mL)]	0.05 (-0.03, 0.12)	0.21	0.06 (0.01, 0.12)	0.04*
UtA- PI	Log [Aldosterone/renin ratio]	-0.05 (-0.10, 0.01)	0.08	-0.03 (-0.09, 0.02)	0.25
MAP (mmHg)	Log [Prorenin (pg/mL)]	-0.03 (-0.06, -0.01)	0.002*	-0.02 (-0.04, 0.01)	0.14
MAP (mmHg)	Log [Aldosterone/renin ratio]	0.01 (-0.01, 0.02)	0.34	0.01 (-0.01, 0.03)	0.19
Second-and third trimester trajectories (n = 201)
UmbA-RI	Log [Prorenin (pg/mL)]	0.01 (-0.004, 0.03)	0.15	0.02 (-0.001, 0.04)	0.06
UmbA-RI	Log [Aldosterone/renin ratio]	-0.01 (-0.02, 0.01)	0.31	-0.004 (-0.02, 0.01)	0.55
UmbA-PI	Log [Prorenin (pg/mL)]	0.04 (-0.004, 0.08)	0.08	0.05 (0.01, 0.11)	0.04*
UmbA-PI	Log [Aldosterone/renin ratio]	-0.02 (-0.05, 0.01)	0.24	-0.01 (-0.05, 0.02)	0.43
At Birth (n = 82)
Placental weight (gram)	Log [Prorenin (pg/mL)]	-50.88 (-109.52; 7.76)	0.09	-93.82 (-160.30; -27.36)	0.006*
Placental weight (gram)	Log [Aldosterone/renin ratio]	24.72 (-16,77; 66.21)	0.24	36.22 (-7.02; 79.45)	0.08

Table shows the effect estimates of the repeated measurements model for the associations of logarithmic transformed maternal total prorenin and aldosterone/renin ratio concentrations at 11 weeks gestation with trajectories of PV and uPVV during the first-trimester, UtA RI/PI and MAP throughout pregnancy and UmbA RI/PI during the second-and third trimester in the total study population and the linear model with placental weight at birth. Model 1: adjusted for gestational age, Model 2: adjusted model for gestational age, corpus luteum number, maternal age, maternal smoking, BMI, parity, fetal gender and polycystic ovary syndrome.*p < 0.05. CI = confidence interval; PV, placental volume; uPVV, utero-placental vascular volume; UtA, uterine artery; RI, restistance index; PI, pulsatility index; MAP, mean arterial pressure; UmbA = umbilical artery

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ISSN: 1477-7827

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