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Table 2 Longitudinal study of utero-placental (vascular) development trajectories and placental weight stratified by corpus luteum number

From: Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort

  7 weeks 9 weeks 11 weeks 13 weeks 22 weeks 32 weeks At birth
GA (days) 0 CL 52 [51;54] 67 [65;67] 81 [79;81] 96 [94;97] 160 [157;161] 227 [226;230] 273 [271;280]
1 CL 51 [50;54] 66 [65;67] 79 [78;82] 93 [92;94] 157 [155;159] 226 [224;228] 273 [265;279]
> 1 CL 51 [50;54] 66 [65;67] 79 [78;82] 93 [92;94] 157 [155;159] 226 [224;228] 275 [269;284]
PV (cm3) 0 CL 12.8 ± 8.7 43.7 ± 15.1 94.4 ± 8.8     
1 CL 17.8 ± 10.7 45.5 ± 16.4 98.0 ± 33.8     
> 1 CL 15.2 ± 7.7 49.5 ± 21.8 102.1 ± 34.7     
uPVV (cm3) 0 CL 5.1 ± 7.3 11.2 ± 4.9 19.4 ± 8.6     
1 CL 3.7 ± 3.3 9.9 ± 7.0 19.0 ± 10.5     
> 1 CL 2.7 ± 2.7*3 10.4 ± 10.1 17.4 ± 14.2     
UtA RI 0 CL 0.82 ± 0.06 0.75 ± 0.07 0.70 ± 0.15 0.59 ± 0.14**1,2 0.39 ± 0.05***1,2 0.44 ± 0.08  
1 CL 0.86 ± 0.08 0.81 ± 0.09 0.76 ± 0.10 0.72 ± 0.10 0.54 ± 0.09 0.49 ± 0.09  
> 1 CL 0.83 ± 0.05*3 0.80 ± 0.07 0.75 ± 0.08 0.71 ± 0.09 0.55 ± 0.09 0.50 ± 0.07  
UtA PI 0 CL 2.36 ± 0.66 1.87 ± 0.53 1.92 ± 1.46 1.39 ± 0.85*1 0.53 ± 0.09***1,2 0.62 ± 0.16*2  
1 CL 2.75 ± 0.78 2.29 ± 0.73 1.96 ± 0.69 1.68 ± 0.60 0.90 ± 0.30 0.77 ± 0.27  
> 1 CL 2.38 ± 0.50**3 2.10 ± 0.46 1.81 ± 0.60 1.60 ± 0.52 0.93 ± 0.29 0.78 ± 0.21  
MAP (mmHg) 0 CL 80.8 ± 12.1 82.9 ± 9.9 84.0 ± 5.1 86.2 ± 8.7 76.1 ± 8.2 75.7 ± 6.7*1  
1 CL 80.4 ± 7.0 83.0 ± 8.1 83.9 ± 8.1 82.6 ± 7.5 78.5 ± 8.7 83.0 ± 9.3  
> 1 CL 79.7 ± 7.2 81.2 ± 7.1 82.7 ± 7.1 81.0 ± 6.5 78.3 ± 6.7 80.5 ± 8.1  
UmbA RI 0 CL      0.68 ± 0.04 0.61 ± 0.05  
1 CL      0.70 ± 0.05 0.61 ± 0.07  
> 1 CL      0.68 ± 0.06 0.63 ± 0.07  
UmbA PI 0 CL      1.09 ± 0.13 0.91 ± 0.11  
1 CL      1.15 ± 0.16 0.94 ± 0.16  
> 1 CL      1.11 ± 0.17 0.98 ± 0.16  
Placental Weight (gram) 0 CL        380 [260;426]
1 CL        438 [360;514]
> 1 CL        491 [433;563]
  1. Data are presented as (mean ± SD) or median (interquartile range). ***p < 0.001, **p < 0.01, *p < 0.05. 1, statistical difference between 0 CL and 1 CL; 2, statistical difference between 0 CL and > 1 CL; 3, statistical difference between 1 CL and > 1 CL. CL = corpus luteum; GA = gestational age; PV = placental volume; uPVV = utero-placental vascular volume; UtA = uterine artery; RI = resistance index; PI = pulsatility index; MAP = mean arterial pressure; UmbA = umbilical artery