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Fig. 4 | Reproductive Biology and Endocrinology

Fig. 4

From: Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort

Fig. 4

Utero-Placental (vascular) Volume trajectories for pregnancies with higher (mean + SD) and lower (mean – SD) prorenin concentrations or aldosterone/renin ratio at baseline for 11 weeks gestation in the total study population. In the fully adjusted model 2, high maternal prorenin concentrations (mean + 2SD) corresponds to a lower utero-placental vascular volume (at 11 weeks gestation -5.26 cm3) and a high A/R ratio (mean + 2SD) corresponds to a larger placental volume (at 11 weeks gestation +11.15 cm3) compared to the mean A/R ratio. Full adjustment includes gestational age, corpus luteum number, maternal age, parity, BMI, smoking, fetal gender and PCOS. Abbreviations: SD = standard deviation. A/R ratio = aldosterone/renin ratio

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