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Table 1 Baseline characteristics and pregnancy outcomes of patients with single frozen-thawed euploid blastocyst transfer

From: Effect of endometrial thickness changes on clinical pregnancy rates after progesterone administration in a single frozen-thawed euploid blastocyst transfer cycle using natural cycles with luteal support for PGT-SR- and PGT-M-assisted reproduction: a retrospective cohort study

Characteristics Total Compaction Non-change Expansion P value
N 219 55 (25.11%) 66 (30.14%) 98 (44.75%)  
Female age at oocyte retrieval (y) 30.21 ± 3.87 30.85 ± 4.40 30.88 ± 3.85 29.41 ± 3.44 0.021
BMI (kg/m2) 22.47 ± 2.66 22.97 ± 2.59 22.84 ± 2.59 21.93 ± 2.67 0.025
Infertility duration (y) 2.00 (1.00–4.00) 2.00 (1.00–4.00) 2.00 (1.00–4.00) 2.00 (1.00–3.80) 0.630
Infertility type (%)      0.943
 Primary 60 (27.40%) 16 (29.09%) 18 (27.27%) 26 (26.53%)  
 Secondary 159 (72.60%) 39 (70.91%) 48 (72.73%) 72 (73.47%)  
Gravidity 2.00 (0.00, 3.00) 2.00 (0.00, 3.00) 2.00 (0.00, 2.00) 2.00 (0.00, 2.00) 0.277
Parity, Mean ± SD (Range) 0.48 ± 0.71 (0.00–3.00) 0.55 ± 0.77 (0.00–3.00) 0.48 ± 0.73 (0.00–3.00) 0.45 ± 0.66 (0.00–3.00) 0.722
No. of miscarriages 1.00 (0.00, 2.00) 1.00 (0.00, 2.00) 1.00 (0.00, 2.00) 1.00 (0.00, 2.00) 0.418
Basal serum FSH (mIU/ml) 6.80 ± 1.99 6.95 ± 2.82 6.98 ± 1.78 6.58 ± 1.49 0.368
AMH (ng/ml) 3.00 (1.90, 4.50) 3.30 (2.10, 5.20) 2.70 (1.90, 3.90) 3.00 (2.10, 5.00) 0.082
No. of retrieved oocytes 16.00 (12.00, 21.00) 16.00 (12.00, 21.00) 15.50 (12.20, 20.00) 17.00 (13.00, 21.80) 0.686
Genetic category (%)      0.548
 Reciprocal translocation 118 (53.88%) 33 (60.00%) 35 (53.03%) 50 (51.02%)  
 Robertsonian translocation 41 (18.72%) 6 (10.91%) 14 (21.21%) 21 (21.43%)  
 Single gene disorders 60 (27.40%) 16 (29.09%) 17 (25.76%) 27 (27.55%)  
Female age at blastocyst transfer (y) 30.49 ± 3.80 31.13 ± 4.33 31.12 ± 3.76 29.71 ± 3.39 0.024
Endometrial thickness on the day of P administration (mm) 10.18 ± 1.99 11.16 ± 2.00 10.20 ± 2.09 9.62 ± 1.71 < 0.001
Endometrial thickness at transfer (mm) 10.45 ± 2.01 9.60 ± 1.68 10.20 ± 2.09 11.09 ± 1.92 < 0.001
Triple-line endometrial pattern on the day of P administration (%)      0.856
 A 196 (89.50%) 50 (90.91%) 58 (87.88%) 88 (89.80%)  
 B 23 (10.50%) 5 (9.09%) 8 (12.12%) 10 (10.20%)  
E2 on the day of P administration (pg/mL) 124.20 (83.50, 174.80) 127.40 (92.40, 212.00) 122.80 (82.20, 155.50) 117.70 (80.40, 171.60) 0.226
LH on the day of P administration (mIU/ml) 19.30 (12.70, 29.20) 20.70 (14.40, 31.10) 19.70 (12.20, 31.40) 18.10 (12.10, 26.90) 0.744
P on the day of P administration (ng/ml) 1.10 (0.90, 1.40) 1.10 (0.80, 1.30) 1.10 (0.90, 1.40) 1.20 (1.00, 1.60) 0.094
Embryo expansion grade at transfer 3.42 ± 0.86 3.46 ± 0.95 3.52 ± 0.95 3.33 ± 0.74 0.353
Embryo inner cell mass grade at transfer (%)      0.236
 A 15 (6.88%) 1 (1.85%) 6 (9.09%) 8 (8.16%)  
 B 203 (93.12%) 53 (98.15%) 60 (90.91%) 90 (91.84%)  
Embryo trophectoderm grade at transfer (%)      0.699
 A 1 (0.46%) 0 (0.00%) 0 (0.00%) 1 (1.02%)  
 B 117 (53.67%) 26 (48.15%) 37 (56.06%) 54 (55.10%)  
 C 100 (45.87%) 28 (51.85%) 29 (43.94%) 43 (43.88%)  
Morphology score (%)      0.281
  < 4 BC 147 (67.43%) 36 (66.67%) 40 (60.61%) 71 (72.45%)  
  ≥ 4 BC 71 (32.57%) 18 (33.33%) 26 (39.39%) 27 (27.55%)  
Day of embryo development at transfer (%)      0.706
 Day 5 156 (71.56%) 38 (69.09%) 49 (75.38%) 69 (70.41%)  
 Day 6 62 (28.44%) 17 (30.91%) 16 (24.62%) 29 (29.59%)  
Clinical pregnancy rate (%) 131 (59.82%) 25 (45.45%) 42 (63.64%) 64 (65.31%) 0.042
Miscarriage rate (%) 21 (16.03%) 2 (8.00%) 5 (11.90%) 14 (21.88%) 0.187
Live-birth rate (%) 111 (56.63%) 23 (46.94%) 37 (64.91%) 51 (56.67%) 0.177
  1. Note: BMI body mass index, FSH follicle-stimulating hormone, AMH anti-Müllerian hormone, P progesterone, E2 estradiol, LH luteinizing hormone