Fig. 1

Metabolic and structural profile development in HFD fed mice. A Body weight gain of mice on HFD exceeded their counterpart fed instead a ND (n = 30, **P < 0.01). Abdominal fat weight (B), the ratio of abdominal fat weight to body weight (C) and serum lipids including CHOL, HDL and LDL in HFD mice content were also significantly higher than those in the ND control group. TGL levels in the HFD and ND groups were not different from one another (D). The data were present as mean ± SD (n = 20, **P < 0.01). E-F Hematoxylin and eosin (H&E) stained hepatic sections revealed a serious hepatic steatosis and many fat vacuoles in the HFD mice (F, arrows indicating fat vacuoles), but no morphological changes developed in liver sections of ND mice (E). Each group was consistently composed of three females. Scale bar = 100 μm