Fig. 2

Identification of the differential metabolomics profiles of FF between DOR and NOR patients based on a volcano plot and hierarchical clustering analysis. a. Volcano plot, down-regulated and up-regulated metabolites in DOR compared to NOR are marked in blue and red, respectively. The X-axis represents the log2 fold change of metabolites, while the Y-axis represents the fold change of the –log10 P value determined by the Student’s t-test. The variable importance in the projection (VIP) value is represented by the dot size. b. Heatmap of the hierarchical clustering analysis. There are fifteen distinct metabolites presented