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Table 2 Summary of results of meta-analyses of comparison between sequential transfer and cleavage embryo transfer

From: Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review

Outcome indicator Studies Samples Heterogeneity Effect model RR (95%CI) P value
Chemical pregnancy 3 423 P=0.73 I2=0% Fixed 1.59 (1.21-2.09) <0.01*
Clinical pregnancy 10 2474 P=0.19 I2=28% Fixed 1.42(1.26-1.60) <0.01*
RIF 6 1440 P=0.03 I2=59% Random 1.58 (1.17–2.13) <0.01*
NRIF 4 1034 P=0.97 I2=0% Random 1.44 (1.20–1.66) <0.01*
Embryo implantation 4 3206 P<0.01 I2=89% Random 1.67 (0.89–3.14) 0.11
Clinical miscarriage 5 517 P=0.19 I2=35% Fixed 0.83(0.57-1.22) 0.35
RIF 3 315 P=0.39 I2=0% Fixed 1.12 (0.71–1.77) 0.62
NRIF 2 202 P=0.34 I2=0% Fixed 0.50 (0.25–1.02) 0.06
Multiple pregnancy 8 642 P=0.25 I2=23% Fixed 1.10(0.83-1.47) 0.05
RIF 6 440 P=0.43 I2=0% Fixed 1.47 (1.01–2.16) 0.05
NRIF 2 202 P=0.19 I2=35% Fixed 0.72 ( 0.45–1.14) 0.16
Live birth 2 531 P=0.91 I2=0% Fixed 1.99 (1.47–2.71) <0.01*
  1. Abbreviations: NRIF Non-RIF;*P<0.01