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Table 1 Characteristics of the 12 studies included in the meta-analysis

From: Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review

Author Year Country Study design RIF Samples (n) Age (mean±SD) Embryo transfer protocol
      Observation Control Observation Control Observation Control
B.Almog [10] 2008 Israel Retrospective Cohort Study Y 65 66 34.3±0.7 34.7±0.1 D2/3 and D5 sequential embryo transfer D2/3 embryo transfer
Simon J [11] 2003 Canada Retrospective Cohort Study N 110 35 34.7±3.5 32.0±4.4 Consecutive transfer Single transfer
Wael A [12] 2015 Egypt Randomized controlled trial Y 74 73 34.4±1.4 34.0±1.5 Sequential D3/D5 embryo transfer D3 embryo transfer
Cong Fang [13] 2012 China Case Control Study Y 66 D3:29 D5:85 34.1±3.2 D3:33.9±4.1
D5:33.1±4.5
Sequential D3/D5 embryo transfer D3 embryo transfer/
D5 embryo transfer
KOICHI KYONO [14] 2003 Japan Retrospective Cohort Study Y 141 D3567 D5:105 35.4±4.5 D3:35.5±4.8 D5:35.±4.5 D3 and blastocyst sequential transfer Early stage embryos/
blastocyst embryo transfer
RonitMachtinger [15] 2006 Israel Retrospective Cohort Study Y 66 117 30.7±3.2 31.0±2.9 Sequential
transfer D3 and D 5/6 embryos
Transfer embryos on D3
Sakae Goto [16] 2005 Japan Prospective Cohort Study Y 90 90 37.4±5.1 37.7±4.8 Sequential transfer D2 and D5 embryos D2embryos transfer
ChadiYazbeck [17] 2011 France Retrospective Cohort Study NS 120 280 33.1±4.1 33.6±3.9 D2/3 and D5/6 embryo sequential transfer D2/3 embryo transfer
Gözde Kaya [18] 2020 Turkey Prospective Cohort Study N 53 135 29.0 31.0 D3 and D5 embryos sequential transfer D2/3 embryo transfer
Jacob Ashkenazi [19] 2000 Israel Retrospective Cohort Study NS 136 139 31.1±4.9 32.2±5.6 Double transfer Early transfer
EnsiehShahrokhTehraninejad [20] 2019 Iran Randomized Clinical trial Y 60 60 35.0 ± 4.4 34.1± 4.2 D3 and D5 embryos sequential transfer D5 embryos transfer
D.Loutradis [21] 2004 Greece Prospective Cohort Study Y 44 42 34.95±4.9 36.2±0.7 2 embryo transfer on D2 and D4/5 Embryo transfer on D4/5
  1. Y yes, N no, NS not suitable, D3 day3, D5 day5