Table 1 Characteristics of the 12 studies included in the meta-analysis
From: Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review
Author | Year | Country | Study design | RIF | Samples (n) | Age (mean±SD) | Embryo transfer protocol | |||
|---|---|---|---|---|---|---|---|---|---|---|
Observation | Control | Observation | Control | Observation | Control | |||||
B.Almog [10] | 2008 | Israel | Retrospective Cohort Study | Y | 65 | 66 | 34.3±0.7 | 34.7±0.1 | D2/3 and D5 sequential embryo transfer | D2/3 embryo transfer |
Simon J [11] | 2003 | Canada | Retrospective Cohort Study | N | 110 | 35 | 34.7±3.5 | 32.0±4.4 | Consecutive transfer | Single transfer |
Wael A [12] | 2015 | Egypt | Randomized controlled trial | Y | 74 | 73 | 34.4±1.4 | 34.0±1.5 | Sequential D3/D5 embryo transfer | D3 embryo transfer |
Cong Fang [13] | 2012 | China | Case Control Study | Y | 66 | D3:29 D5:85 | 34.1±3.2 | D3:33.9±4.1 D5:33.1±4.5 | Sequential D3/D5 embryo transfer | D3 embryo transfer/ D5 embryo transfer |
KOICHI KYONO [14] | 2003 | Japan | Retrospective Cohort Study | Y | 141 | D3567 D5:105 | 35.4±4.5 | D3:35.5±4.8 D5:35.±4.5 | D3 and blastocyst sequential transfer | Early stage embryos/ blastocyst embryo transfer |
RonitMachtinger [15] | 2006 | Israel | Retrospective Cohort Study | Y | 66 | 117 | 30.7±3.2 | 31.0±2.9 | Sequential transfer D3 and D 5/6 embryos | Transfer embryos on D3 |
Sakae Goto [16] | 2005 | Japan | Prospective Cohort Study | Y | 90 | 90 | 37.4±5.1 | 37.7±4.8 | Sequential transfer D2 and D5 embryos | D2embryos transfer |
ChadiYazbeck [17] | 2011 | France | Retrospective Cohort Study | NS | 120 | 280 | 33.1±4.1 | 33.6±3.9 | D2/3 and D5/6 embryo sequential transfer | D2/3 embryo transfer |
Gözde Kaya [18] | 2020 | Turkey | Prospective Cohort Study | N | 53 | 135 | 29.0 | 31.0 | D3 and D5 embryos sequential transfer | D2/3 embryo transfer |
Jacob Ashkenazi [19] | 2000 | Israel | Retrospective Cohort Study | NS | 136 | 139 | 31.1±4.9 | 32.2±5.6 | Double transfer | Early transfer |
EnsiehShahrokhTehraninejad [20] | 2019 | Iran | Randomized Clinical trial | Y | 60 | 60 | 35.0 ± 4.4 | 34.1± 4.2 | D3 and D5 embryos sequential transfer | D5 embryos transfer |
D.Loutradis [21] | 2004 | Greece | Prospective Cohort Study | Y | 44 | 42 | 34.95±4.9 | 36.2±0.7 | 2 embryo transfer on D2 and D4/5 | Embryo transfer on D4/5 |