|
Pregnancy outcomes
|
Timing of initial FET
|
Crude model a
|
Adjusted model I b
|
Adjusted model II c
|
|---|
|
OR (95% CI)
|
P value
|
OR (95% CI)
|
P value
|
OR (95% CI)
|
P value
|
|---|
|
Positive pregnancy
|
Immediate FET group
|
Reference
| |
Reference
| |
Reference
| |
|
Delayed FET group
|
1.09 (0.80to 1.48)
|
0.587
|
1.04 (0.75 to 1.44)
|
0.810
|
0.95 (0.67 to 1.35)
|
0.781
|
|
Clinical pregnancy
|
Immediate FET group
|
Reference
| |
Reference
| |
Reference
| |
|
Delayed FET group
|
0.74 (0.54 to 1.02)
|
0.066
|
0.70 (0.50 to 0.97)
|
0.031
|
0.68 (0.47 to 0.97)
|
0.031
|
|
Ongoing pregnancy
|
Immediate FET group
|
Reference
| |
Reference
| |
Reference
| |
|
Delayed FET group
|
0.78 (0.55 to 1.05)
|
0.096
|
0.71 (0.51 to 0.99)
|
0.048
|
0.68 (0.47 to 0.99)
|
0.041
|
|
Live birth
|
Immediate FET group
|
Reference
| |
Reference
| |
Reference
| |
|
Delayed FET group
|
0.75 (0.54 to 1.04)
|
0.080
|
0.70 (0.50 to 0.98)
|
0.038
|
0.67 (0.46 to 0.96)
|
0.031
|
- Abbreviation: AMH Anti-müllerian hormone, BMI Body mass index, FSH Follicle stimulating hormone, OR Odds ratio, CI Confidence interval, FET Frozen embryo transfer, IVF-ET In vitro fertilization-embryo transfer, AFC Antral follicle count, COS Controlled ovarian stimulation; Gn, gonadotropin
- a No adjustments for other covariates
- b Adjusted for female age (< 35 yrs., ≥ 35 yrs.), moderate/severe depression prior to FET (yes, no), and high stress level prior to FET (yes, no)
- c Adjusted for female age (< 35 yrs., ≥ 35 yrs.), AMH (< 1.2 ng/ml, ≥ 1.2 ng/ml), BMI (< 24 kg/m2, ≥ 24 kg/m2), basic FSH (< 10 UI/L, ≥ 10 UI/L), AFC (< 10, ≥ 10), endometrial thickness before FET, No of oocytes retrieved (≤ 9, > 9), No of transferred frozen thawed embryos (single, double), method of fertilization (IVF, ICSI), moderate/severe depression prior to FET (yes, no), and high stress level prior to FET (yes, no)
