Skip to main content

Table 3 Relationship between the timing of initial FET after a fresh IVF-ET attempt failure and pregnancy outcomes in different models

From: Immediate versus delayed frozen embryo transfer in women following a failed IVF-ET attempt: a multicenter randomized controlled trial

Pregnancy outcomes Timing of initial FET Crude model a Adjusted model I b Adjusted model II c
OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
Positive pregnancy Immediate FET group Reference   Reference   Reference  
Delayed FET group 1.09 (0.80to 1.48) 0.587 1.04 (0.75 to 1.44) 0.810 0.95 (0.67 to 1.35) 0.781
Clinical pregnancy Immediate FET group Reference   Reference   Reference  
Delayed FET group 0.74 (0.54 to 1.02) 0.066 0.70 (0.50 to 0.97) 0.031 0.68 (0.47 to 0.97) 0.031
Ongoing pregnancy Immediate FET group Reference   Reference   Reference  
Delayed FET group 0.78 (0.55 to 1.05) 0.096 0.71 (0.51 to 0.99) 0.048 0.68 (0.47 to 0.99) 0.041
Live birth Immediate FET group Reference   Reference   Reference  
Delayed FET group 0.75 (0.54 to 1.04) 0.080 0.70 (0.50 to 0.98) 0.038 0.67 (0.46 to 0.96) 0.031
  1. Abbreviation: AMH Anti-müllerian hormone, BMI Body mass index, FSH Follicle stimulating hormone, OR Odds ratio, CI Confidence interval, FET Frozen embryo transfer, IVF-ET In vitro fertilization-embryo transfer, AFC Antral follicle count, COS Controlled ovarian stimulation; Gn, gonadotropin
  2. a No adjustments for other covariates
  3. b Adjusted for female age (< 35 yrs., ≥ 35 yrs.), moderate/severe depression prior to FET (yes, no), and high stress level prior to FET (yes, no)
  4. c Adjusted for female age (< 35 yrs., ≥ 35 yrs.), AMH (< 1.2 ng/ml, ≥ 1.2 ng/ml), BMI (< 24 kg/m2, ≥ 24 kg/m2), basic FSH (< 10 UI/L, ≥ 10 UI/L), AFC (< 10, ≥ 10), endometrial thickness before FET, No of oocytes retrieved (≤ 9, > 9), No of transferred frozen thawed embryos (single, double), method of fertilization (IVF, ICSI), moderate/severe depression prior to FET (yes, no), and high stress level prior to FET (yes, no)