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Table 1 Basal demographic and cycle features of FETs which proceeded either within the immediate cycle following OPU (Immediate FET group) or subsequently (Delayed FET group) after a failed-fresh ET. Data are presented as numbers (%) unless otherwise noted

From: Immediate versus delayed frozen embryo transfer in women following a failed IVF-ET attempt: a multicenter randomized controlled trial

Characteristic

Immediate FET group

Delayed FET group

P-value

Randomized subjects

366

366

 

Female age at oocyte retrieval (years; mean (SD))

33.8 (3.2)

33.3 (4.1)

0.062

Etiology of infertility

  

0.815

 Tubal factor

184 (50.3)

177 (48.4)

 

 Anovulation

43 (11.7)

36 (9.8)

 

 Male factor

59 (16.1)

63 (17.2)

 

 Combined factor

68 (18.6)

75 (20.5)

 

 Unexplained sterility

12 (3.3)

15 (4.1)

 

FET interval (days; mean (SD))

25.2 (5.4)

103.5 (23.3)

< 0.001

Duration of infertility (years; median (IQR))

4 (4)

5 (2)

0.817

Nulliparous

176 (48.1)

180 (49.2)

0.767

Gravidity (median (IQR))

1 (2)

1 (2)

0.978

Parity (median (IQR))

0 (1)

0 (1)

0.844

BMI (kg/m2; mean (SD))

23.1 (2.9)

23.5 (2.9)

0.116

AMH (ng/ml; median (IQR))

2.9 (1.6)

3.1 (1.2)

0.354

Basic FSH (mIU/ml; mean (SD))

6.7 (1.0)

6.8 (1.9)

0.920

Basic LH (mIU/ml; mean (SD))

5.0 (1.5)

5.0 (1.2)

0.688

Basic estradiol (pg/ml; median (IQR))

35.4 (7.0)

35.3 (8.4)

0.755

Total AFC (mean (SD))

10.4 (3.2)

10.7 (2.9)

0.329

No of days of COS (mean (SD))

10.7 (2.1)

10.9 (1.8)

0.132

Total Gn dose administered (IU; mean (SD))

2140.5 (469.3)

2180.5 (551.2)

0.291

Method of fertilization

  

0.875

 IVF

247 (67.5)

245 (66.9)

 

 ICSI

119 (32.5)

121 (33.1)

 

No of oocytes retrieved (mean (SD))

10.5 (2.1)

10.7 (2.8)

0.170

No of embryos available for transfer (median (IQR))

5.5 (2)

5 (5)

0.235

No of high-quality day 3 embryos (median (IQR))

2 (0)

2 (2)

0.315

No of embryos transferred in fresh ET cycle (median (IQR))

2 (0)

2 (0)

0.697

 Single embryo transfer

31 (8.5)

34 (9.3)

 

 Double embryo transfer

335 (91.5)

332 (90.7)

 

No of frozen thawed embryos transferred (median (IQR))

2 (0)

2 (0)

0.956

 Single embryo transfer

32 (9.8)

31 (9.7)

 

 Double embryo transfer

294 (90.2)

289 (90.3)

 

Endometrial thickness prior to FET (mm; mean (SD))

10.5 (1.8)

10.3 (1.9)

0.388

Moderate/severe depression prior to FET (MDI) a

20/326 (6.1)

34/320 (10.6)

0.039

High stress level prior to FET (PSS) b

73/326 (22.4)

97/320 (30.3)

0.022

  1. Abbreviation: FET Frozen embryo transfer, IQR Interquartile range, OPU Ovum pick-up, Interval Days elapsed from oocyte retrieval to frozen embryo transfer, BMI Body mass index, AMH Anti-müllerian hormone, FSH Follicle stimulating hormone, LH Luteinizing hormone, AFC Antral follicle count, COS Controlled ovarian stimulation, IVF In-vitro fertilization, ICSI Intracytoplasmic sperm injection, Gn Gonadotropin, IU International units, MDI Major Depression Index, PSS Cohen’s Perceived Stress Scale
  2. a Moderate depression (two core symptoms and four or more additional symptoms); Severe depression (three core symptoms and five or more additional symptoms)
  3. b High stress level defined as ≥ 19 on the PSS scale