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Fig. 6 | Reproductive Biology and Endocrinology

Fig. 6

From: Single-cell transcriptome and cell-specific network analysis reveal the reparative effect of neurotrophin-4 in preantral follicles grown in vitro

Fig. 6

Effect of NT-4 on transcriptome of granulosa cells from Day 6 follicles and their interaction with oocyte. a KEGG enrichment of over-expressed genes of granulosa cells in IVG-NT group. b KEGG enrichment of over-expressed genes of granulosa cells in IVG group. c, d, e Quantitative RT-PCR detection of Ugt1a7c (c), Fga (d), C3 (e) transcripts in granulosa cells from Day 6 follicles. *, P < 0·05. f, g, h The overlap of GO enrichment of oocyte and granulosa cells DEGs (IVG-NT vs. IVG), including pathway-related (f), hormone-related (g), and extracellular matrix-related (h). i The interaction between oocyte and granulosa cells from follicles cultured in vitro for six days (with or without NT-4) using CellTalkDB tool. Blue represents genes of granulosa cells, and pink represents genes of oocytes. The origin of arrows represents ligand, and the terminal represents receptor. Each group contains two granulosa cell samples from independent experiments

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