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Fig. 5 | Reproductive Biology and Endocrinology

Fig. 5

From: Single-cell transcriptome and cell-specific network analysis reveal the reparative effect of neurotrophin-4 in preantral follicles grown in vitro

Fig. 5

Effect of NT-4 on transcriptome of oocytes from follicles cultured in vitro for six days. a KEGG enrichment analysis of upregulated different-expressed genes (DEGs) in IVG-NT oocytes compared with IVG oocytes from follicles cultured in vitro for six days. b KEGG enrichment analysis of downregulated DEGs in IVG-NT oocytes than IVG oocytes from follicles cultured in vitro for six days. c Cytoscape plots from DEGs and predicted transcription factors (with red circles) were given as an input to be used as potential regulators of the network. d GO terms of DEGs which are simultaneously targeted by the predicted transcription factors. e Definitions and GO enrichment analyses of ‘Activator’, ‘Sustainer’ and ‘Phenotype’ gene sets according to the overlap of DEGs from oocyte cultured in vitro for ten days (GV) and six days. Each group contains three samples from three independent experiments

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