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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Single-cell transcriptome and cell-specific network analysis reveal the reparative effect of neurotrophin-4 in preantral follicles grown in vitro

Fig. 2

The administration of NT-4 in the culture of mice preantral follicle in vitro. a Flow diagram of NT-4 administration to in vitro culture of mice preantral follicle and the corresponding RNA sequencing. Three independent experiments were conducted. b Dynamic of follicle diameter when cultured in vitro (0 ng/mL, 50 ng/mL, 100 ng/mL, 200 ng/mL), n = 99, 95, 98, 96, separately. *, P < 0·05 0 ng/mL vs. 100 ng/mL and 0 ng/mL vs. 200 ng/mL on Day 9. c Survival rate of follicles in Control and NT-4 groups. d The rate of Maturation in Control and NT-4 groups. *, P < 0·05 Control group vs. NT-4 group (100 ng/mL). e, f Hormone profiles of estradiol (e) and progesterone (f) in the Control group and NT-4 group (100 ng/mL) during ten days of in-vitro culture. *, P < 0·05 Control group vs. NT-4 group. ***, P < 0·001 Control group vs. NT-4 group. Data in (b), (e), (f) are presented as mean percentage (mean ± SEM)

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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