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Table 2 Univariate and multivariate Cox regression model of variables associated with pregnancy outcomes in AEH/EEC patients after fertility-sparing treatment

From: Analysis of pregnancy-associated factors after fertility-sparing therapy in young women with early stage endometrial cancer or atypical endometrial hyperplasia

Variables

Non-pregnant

Pregnant

HR (95% CI) P value

N = 32

N = 36

Crude model

Adjusted model I

Adjusted model II

Age of pregnancy permission (years)

32.6 ± 3.8

31.2 ± 4.5

1.0 (0.9, 1.1) 0.717

1.0 (1.0, 1.1) 0.502

1.0 (0.9, 1.1) 0.554

BMI of pregnancy permission (kg/m2)

27.2 ± 3.7

24.8 ± 3.6

0.9 (0.8, 1.0) 0.061

0.9 (0.8, 1.0) 0.045

0.9 (0.8, 1.0) 0.031

  < 24

3 (9.4%)

18 (50.0%)

Refrence

Refrence

Refrence

  ≥ 24

29 (90.6%)

18 (50.0%)

0.4 (0.2, 0.8) 0.012

0.4 (0.2, 0.8) 0.010

0.4 (0.2, 0.8) 0.010

Additional prolonged therapy (months)

2.1 ± 2.6

2.2 ± 1.9

1.0 (0.9, 1.2) 0.794

1.0 (0.9, 1.2) 0.705

1.0 (0.8, 1.2) 0.770

 0

17 (53.1%)

13 (36.1%)

Refrence

Refrence

Refrence

 3

9 (28.1%)

19 (52.8%)

2.1 (1.0, 4.2) 0.044

2.9 (1.2, 7.0) 0.018

3.0 (1.1, 8.3) 0.037

  ≥ 6

6 (18.8%)

4 (11.1%)

0.9 (0.3, 2.7) 0.829

1.2 (0.3, 4.0) 0.817

0.7 (0.2, 2.7) 0.603

Time to CR (months)

6.4 ± 4.0

4.2 ± 2.5

0.9 (0.7, 1.0) 0.049

0.9 (0.7, 1.0) 0.109

0.8 (0.7, 1.0) 0.032

  < 6

12 (37.5%)

28 (77.8%)

Refrence

Refrence

Refrence

  ≥ 6

20 (62.5%)

8 (22.2%)

0.3 (0.1, 0.7) 0.004

0.3 (0.1, 0.8) 0.014

0.2 (0.1, 0.6) 0.004

Intrauterine adhesion

 No

16 (50.0%)

26 (72.2%)

Refrence

Refrence

Refrence

 Yes

16 (50.0%)

10 (27.8%)

0.5 (0.2, 1.1) 0.082

0.6 (0.3, 1.4) 0.244

0.6 (0.3, 1.4) 0.272

Number of HS

4.1 ± 1.2

3.4 ± 1.0

0.7 (0.5, 0.9) 0.007

0.7 (0.5, 1.0) 0.024

0.6 (0.4, 0.8) 0.004

Endometrial thickness after CR (cm)

0.6 ± 0.2

0.7 ± 0.2

5.0 (0.9, 28.8) 0.072

7.3 (0.9, 57.3) 0.058

8.8 (1.1, 73.0) 0.043

Relapse before pregnancy

 No

19 (59.4%)

30 (83.3%)

Refrence

Refrence

Refrence

 Yes

13 (40.6%)

6 (16.7%)

0.3 (0.1, 0.7) 0.006

0.2 (0.1, 0.6) 0.004

0.2 (0.1, 0.5) 0.001

  1. Crude model adjust for: None
  2. Adjust model I adjust for: Histological type; Treatment protocol
  3. Adjust model II adjust for: Histological type; Treatment protocol; HOMA; PCO on ultrasonography; Parity
  4. BMI, kg/m2 (Chinese Society for the Study of Obesity: normal BMI 18.5–23.9; overweight 24–28; obesity > 28)
  5. BMI body mass index, CR complete remission, CI confidence interval, HR hazard ratio, HS hysteroscopy, PCO polycystic ovary