Skip to main content

Table 2 Univariate and multivariate Cox regression model of variables associated with pregnancy outcomes in AEH/EEC patients after fertility-sparing treatment

From: Analysis of pregnancy-associated factors after fertility-sparing therapy in young women with early stage endometrial cancer or atypical endometrial hyperplasia

Variables Non-pregnant Pregnant HR (95% CI) P value
N = 32 N = 36 Crude model Adjusted model I Adjusted model II
Age of pregnancy permission (years) 32.6 ± 3.8 31.2 ± 4.5 1.0 (0.9, 1.1) 0.717 1.0 (1.0, 1.1) 0.502 1.0 (0.9, 1.1) 0.554
BMI of pregnancy permission (kg/m2) 27.2 ± 3.7 24.8 ± 3.6 0.9 (0.8, 1.0) 0.061 0.9 (0.8, 1.0) 0.045 0.9 (0.8, 1.0) 0.031
  < 24 3 (9.4%) 18 (50.0%) Refrence Refrence Refrence
  ≥ 24 29 (90.6%) 18 (50.0%) 0.4 (0.2, 0.8) 0.012 0.4 (0.2, 0.8) 0.010 0.4 (0.2, 0.8) 0.010
Additional prolonged therapy (months) 2.1 ± 2.6 2.2 ± 1.9 1.0 (0.9, 1.2) 0.794 1.0 (0.9, 1.2) 0.705 1.0 (0.8, 1.2) 0.770
 0 17 (53.1%) 13 (36.1%) Refrence Refrence Refrence
 3 9 (28.1%) 19 (52.8%) 2.1 (1.0, 4.2) 0.044 2.9 (1.2, 7.0) 0.018 3.0 (1.1, 8.3) 0.037
  ≥ 6 6 (18.8%) 4 (11.1%) 0.9 (0.3, 2.7) 0.829 1.2 (0.3, 4.0) 0.817 0.7 (0.2, 2.7) 0.603
Time to CR (months) 6.4 ± 4.0 4.2 ± 2.5 0.9 (0.7, 1.0) 0.049 0.9 (0.7, 1.0) 0.109 0.8 (0.7, 1.0) 0.032
  < 6 12 (37.5%) 28 (77.8%) Refrence Refrence Refrence
  ≥ 6 20 (62.5%) 8 (22.2%) 0.3 (0.1, 0.7) 0.004 0.3 (0.1, 0.8) 0.014 0.2 (0.1, 0.6) 0.004
Intrauterine adhesion
 No 16 (50.0%) 26 (72.2%) Refrence Refrence Refrence
 Yes 16 (50.0%) 10 (27.8%) 0.5 (0.2, 1.1) 0.082 0.6 (0.3, 1.4) 0.244 0.6 (0.3, 1.4) 0.272
Number of HS 4.1 ± 1.2 3.4 ± 1.0 0.7 (0.5, 0.9) 0.007 0.7 (0.5, 1.0) 0.024 0.6 (0.4, 0.8) 0.004
Endometrial thickness after CR (cm) 0.6 ± 0.2 0.7 ± 0.2 5.0 (0.9, 28.8) 0.072 7.3 (0.9, 57.3) 0.058 8.8 (1.1, 73.0) 0.043
Relapse before pregnancy
 No 19 (59.4%) 30 (83.3%) Refrence Refrence Refrence
 Yes 13 (40.6%) 6 (16.7%) 0.3 (0.1, 0.7) 0.006 0.2 (0.1, 0.6) 0.004 0.2 (0.1, 0.5) 0.001
  1. Crude model adjust for: None
  2. Adjust model I adjust for: Histological type; Treatment protocol
  3. Adjust model II adjust for: Histological type; Treatment protocol; HOMA; PCO on ultrasonography; Parity
  4. BMI, kg/m2 (Chinese Society for the Study of Obesity: normal BMI 18.5–23.9; overweight 24–28; obesity > 28)
  5. BMI body mass index, CR complete remission, CI confidence interval, HR hazard ratio, HS hysteroscopy, PCO polycystic ovary