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Table 1 Results of GSEA based on the differential expression analysis of RL95-2 cells treated with JAr EVs

From: Trophoblast derived extracellular vesicles specifically alter the transcriptome of endometrial cells and may constitute a critical component of embryo-maternal communication

Reactome ID

Description

NES

FDR

R-HSA-372790

Signalling by G-protein coupled receptor (GPCR)

1.267

0.010

R-HSA-388396

GPCR downstream signalling

1.289

0.010

R-HSA-1474228

Degradation of the extracellular matrix (ECM)

1.479

0.010

R-HSA-1474244

Extracellular matrix organization

1.448

0.010

R-HSA-1474290

Collagen formation

1.490

0.010

R-HSA-216083

Integrin cell surface interactions

1.549

0.010

R-HSA-3000171

Non-integrin membrane-ECM interactions

1.456

0.011

R-HSA-3000157

Laminin interactions

1.568

0.019

R-HSA-3000178

ECM proteoglycans

1.441

0.051

  1. Results of GSEA based on the differential expression analysis of RL95-2 cells supplemented with EVs compared to non-supplemented control group RL95-2 cells. Normalized Enrichment Score (NES) and False Discovery Rate (FDR) are presented