Skip to main content
Fig. 3 | Reproductive Biology and Endocrinology

Fig. 3

From: Trophoblast derived extracellular vesicles specifically alter the transcriptome of endometrial cells and may constitute a critical component of embryo-maternal communication

Fig. 3

The contrast between RNA cargo of JAr EVs and HEK293 EVs. (A) Principal component analysis (PCA) of all genes for which RNA fragments were detected in the total RNA of either the JAr EVs (JAr) or HEK293 EVs (HEK293). The first two principal components (PC) are presented. Clear separation of HEK293 samples from the JAr samples can be seen along the PC1 axis. (B) Differential enrichment of RNA fragments aligning to known gene loci in the JAr EVs and HEK293 EVs. Genes for which the RNA fragments in JAr EVs were enriched compared to HEK293 EVs (FDR ≤ 0.05, log2FC > 1) are coloured orange. Genes for which the RNA fragments in JAr EVs were depleted compared to HEK293 EVs (FDR ≤ 0.05, log2FC < -1) are coloured blue

Back to article page

Reproductive Biology and Endocrinology

ISSN: 1477-7827

Contact us