Fig. 1

Experimental design of the study. Extracellular vesicles (EV) were isolated from trophoblast (JAr) spheroids and non-trophoblast (HEK293) spheroids. The miRNA cargo of the isolated EVs was explored using miRNA sequencing. EVs were supplemented to the endometrial analogue (RL95-2) cells and the transcriptomic alterations of the RL95-2 cells were investigated using RNA sequencing