Fig. 2

Effect of hsa_circ_0081343 overexpression or knockdown on the migration, invasion, and apoptosis of HTR-8 cells. A: hsa_circ_0081343 was overexpressed in HTR-8 cells by transfecting with hsa_circ_0081343 overexpression plasmid (ov-circ_0081343). Transfection with empty pLCD5H-ciR plasmid was used as a negative control (NC). B: hsa_circ_0081343 was silenced in HTR-8 cells by transfecting with two small interfering RNAs (siRNA-1 and -2) targeting hsa_circ_0081343. Transfection with negative control siRNA (si-NC) was used as control. C-E: The effect of hsa_circ_0081343 overexpression or silencing on migration- and apoptosis-related proteins (C), apoptosis (D), and the migration and invasion potential of HTR-8 cells (E). *p < 0.05, when compared to NC; ^#p < 0.05, when compared to si-NC. All experiments were independently performed three times