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Table 2 Effects of different doses of HESS and glibenclamide on gonadal mass and sperm parameters

From: Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide

Groups TW (g)
(single testis)
GSI (%) Total sperm count (× 107) /mLof HTF Viability (%) Motility (%) DNA-damage (%) Abnormality (%) Maturity
NC 1.62 ± 0.09b 0.45 ± 0.05 99.40 ± 2.7 b 89.4 ± 3.6 b 87.8 ± 3.1 b 6.4 ± 1.8 b 11.6 ± 1.8 b 98.4 ± 1.5 b
DC 1.33 ± 0.05a 0.55 ± 0.09 48.60 ± 3.5 a 47.8 ± 5.8 a 54.0 ± 6.0 a 34.2 ± 2.6 a 38.0 ± 3.4 a 84.8 ± 0.5 a
HESS-100 1.44 ± 0.03a 0.53 ± 0.04 50.40 ± 3.6 a 58.4 ± 2.9 a 56.6 ± 6.6 a 30.4 ± 1.1 a 34.0 ± 4.5 a 86.4 ± 2.1 a
HESS-200 1.47 ± 0.07 0.52 ± 0.06 57.80 ± 4.2 a 63.4 ± 4.0 a 60.8 ± 4.8 a 28.8 ± 1.6 a 30.4 ± 5.6 a 87.0 ± 1.2 a
HESS-400 1.52 ± 0.1b 0.53 ± 0.01 60.50 ± 3.1 a 71.0 ± 2.9 a 63.0 ± 5.1 a 24.7 ± 1.3 a 28.0 ± 1.8 a 90.2 ± 1.7 a
G 1.54 ± 0.1b 0.57 ± 0.06 94.20 ± 2.4b 80.0 ± 3.8 b 79.2 ± 4.1 b 11.6 ± 2.4 b 17.2 ± 2.9 b 94.4 ± 2.7 b
G + HESS-200 1.49 ± 0.04b 0.54 ± 0.06 96.80 ± 3.5 b 85.6 ± 4.8 b 82.4 ± 2.4 b 11.0 ± 2.7 b 13.0 ± 3.1 b 95.0 ± 1.6 b
G + HESS-400 1.50 ± 0.05b 0.52 ± 0.06 98.80 ± 1.9 b 86.2 ± 4.3 b 85.4 ± 4.6 b 10.6 ± 2.9 b 11.8 ± 4.1 b 97.0 ± 2.7 b
P-value 0.001 0.93 0.001 0.001 0.001 0.001 0.001 0.001
  1. Testicular weight (TW), gonadosomatic indices (GSI), HESS (hydroalcoholic extract of S. securidaca seeds); G (glibenclamide); DC (diabetic control); NC (normal control)
  2. a: statistically significant difference with NC group
  3. b: statistically significant difference with DC group