Table 6 Dysregulation of circRNAs in PE

hsa_circ_0001438

placenta

upregulated

hsa_circ_0001438, hsa_circ_0001326, and hsa_circ_32340 were upregulated in the sPE patients and the circRNA-miRNA-mRNA interaction network generated with these three circRNAs revealed a broad regulatory network that might be involved in the pathogenesis of sPE

[197]

hsa_circ_0001326

placenta

upregulated

hsa_circ_32340

placenta

upregulated

hsa_circ_101,222

placenta

upregulated

Plasma protein endoglin in combination with circ-101,222 strengthened the predictive power for pre-eclampsia

[198]

hsa_circ_SFXN1

placenta

upregulated

CircSFXN1 overexpression significantly inhibited the invasion of TEV-1 trophoblasts and blocked the angiogenesis of human umbilical vein endothelial cells

[199]

hsa_circ_0011460

placenta

upregulated

Circ-0011460 were involved in vasodilation, regulation of blood vessel size, protein transport and localization

[200]

hsa_circ_0088227

placenta/plasma

downregulated

Knockdown of circPAPPA led to decreased proliferation and invasion in HTR8-S/Vneo trophoblast cells

[13]

hsa_circ_TNRC18

placenta

upregulated

Circ-TNRC18 enhanced trophoblast cell migration and epithelial-mesenchymal transition

[15]

hsa_circ_0014736

placenta

upregulated

the three altered circ-RNAs had a relationship with transcription regulation, proliferation, protein binding, and response to hypoxia

[201]

hsa_circ_0015382

placenta

upregulated

hsa_circ_0007121

placenta

downregulated

hsa_circ_100782

placenta

upregulated

/

[202]

hsa_circ_102682

placenta

upregulated

/

hsa_circ_104820

placenta

upregulated

/

hsa_circ_0001855

placenta

upregulated

Circ-0004904 and circ-0001855 combined with PAPP-A might be promising biomarkers for the detection of PE

[203]

hsa_circ_0004904

placenta

upregulated

hsa_circ_3286

placenta

downregulated

Circ-3286 significantly promoted HTR8/Svneo cell invasion.

[204]

hsa_circ_593

placenta

downregulated

/

hsa_circ_3800

placenta

downregulated

/

hsa_circ_3286

plasma

downregulated

/

hsa_circ_0036877

plasma

upregulated

Circ-0036877 significantly increased apoptosis of syncytial trophoblasts in the PE placenta

[205]

placenta

downregulated

hsa_circ_0036878

placenta

downregulated

/

hsa_circ_0055724

placenta

downregulated

/

hsa_circ_0049730

placenta

downregulated

/

hsa_circ_0036474

placenta

upregulated

/