|
BC030099
|
the whole blood (WB)
|
upregulated
|
/
|
/
|
[137]
|
|
LOC391533
|
placenta
|
upregulated
|
sFlt-1
|
This protein plays an important role in angiogenesis and vasculogenesis.
|
[138]
|
|
LOC284100
|
placenta
|
upregulated
|
/
|
/
|
|
CEACAMP8
|
placenta
|
upregulated
|
/
|
/
|
|
HOTAIR
|
placenta
|
upregulated
|
miR-106a
|
High level of HOTAIR represses the proliferation, migration and invasion of trophoblast cells through downregulating miR-106 in an EZH2-dependent manner.
|
[139]
|
|
downregulated
|
PUM1/HOTAIR
|
HOTAIR promotes trophoblast invasion by activating PI3K-AKT signaling pathway.
|
[140]
|
|
AGAP2-AS1
|
placenta
|
downregulated
|
JDP2
|
AGAP2-AS1 knockdown could inhibit trophoblasts proliferation, invasion and spiral artery remodeling and promote cell apoptosis.
|
[141]
|
|
HOXA11-AS
|
placenta
|
downregulated
|
miR-15b-5p/HOXA-7/Lsd1 and Ezh2/RND3
|
Down-regulated HOXA11-AS inhibits trophoblast cell proliferation, migration and invasion, and promoted cell accumulation in G0–G1 phase and apoptosis.
|
[142]
|
|
TUG1
|
placenta
|
downregulated
|
miR-29b/MCL1/VEGFA /MMP2
|
TUG1 could act as a molecular sponge for miR-29b, thus down-regulating MCL1, VEGFA, and MMP2 to promote cell proliferation, invasion, and angiogenesis, while negatively regulated cell apoptosis.
|
[14]
|
|
Ezh2/RND3
|
Down-regulated TUG1 inhibits trophoblast cell proliferation, migration, invasion and the formation of capillary-like networks and promotes trophoblast cell apoptosis.
|
[143]
|
|
miR-204-5p
|
Down-regulated TUG1 negatively regulates trophoblast migration and invasion partly through sponging miR-204-5p and negatively regulating the expression and function of miR-204-5p.
|
[144]
|
|
SPRY4-IT1
|
placenta
|
upregulated
|
Bax/Bcl-2
|
SPRY4-IT1 overexpression significantly decreases the cell migration, proliferation and spiral artery remodeling, while increases cell apoptosis.
|
[145]
|
|
Wnt/β-catenin pathway
|
Overexpression of SPRY4-IT1 suppresses trophoblast cell migration, invasion and spiral artery remodeling by inducing E-cadherin and β-catenin expression and decreasing vimentin expression.
|
[146]
|
|
MEG3
|
placenta
|
downregulated
|
TGF-β/ /E-cadherin/N-cadherin
|
Down-regulated MEG3 induces E-cadherin upregulation and N-cadherin and slug downregulation in HTR-8/SVneo cells, which inhibits trophoblast cell proliferation, migration, invasion and EMT.
|
[147]
|
|
Notch1
|
Down-regulation of MEG3 could downregulate Notch1 expression to suppress trophoblast cells migration, invasion and promote its apoptosis.
|
[148]
|
|
NF-κB/Caspase-3/ Bax
|
Down-regulation of MEG3 increases apoptosis and decreases migration of trophoblast cells by influencing expression of NF-κB, Caspase-3, and Bax protein expressions.
|
[149]
|
|
H19
|
placenta
|
downregulated
|
NOMO1/miR-675
|
Lowered expression of H19 participate in the excessive proliferation of trophoblast cells by downregulating miR-675 which targets NOMO1 and interferes with Nodal signaling.
|
[150]
|
|
miR-148a-5p/P28/miR-216-3p/EBI3
|
Down-regulated could up-regulate the expression of miR-148-5p/miR-216-3p and the expressions of subunits of IL-27, P28 and EBI3 were thus suppressed.
|
[151]
|
|
miRNAlet-7/the type III TGF-β receptor (TβR3)
|
H19 repression decreases TGF-β signaling via the Par6/Smurf1/RhoA pathway activated by TβR3, leading to impaired migration and invasion of EVT cells.
|
[152]
|
|
upregulated
|
PI3K/AKT/mTOR pathways
|
LncRNA-H19 overexpression reduces cell viability but increases invasion and autophagy in trophoblast cells by enhancing phosphorylated levels of key kinases in the PI3K/AKT/mTOR pathways.
|
[153]
|
|
MIR503HG
|
placenta
|
upregulated
|
the matrix metalloproteinase-2/− 9, the snail /E-cadherin/ NF-κB signaling pathway
|
MIR503HG overexpression suppresses cell proliferation, invasion, and migration, and induces apoptosis and causes cell cycle arrest at the G0/G1 phase of HTR-8/SVneo
|
[154]
|
|
DLX6-AS1
|
placenta tissues
|
upregulated
|
miR-149–5p/ERP44 pathway
|
DLX6-AS1 inhibits proliferation and invasion of trophoblast cells, and suppresses angiogenesis of HUVEC cells by binding miR-149–5p/ERP44 pathway.
|
[11]
|
|
miR-376c/ GADD45A
|
DLX6-AS1 may contribute to preeclampsia by impairing proliferative, migratory and invasive abilities of trophoblasts via the miR-376c/GADD45A axis.
|
[155]
|
|
ZEB2-AS1
|
placenta
|
downregulated
|
miR-149 / PGF
|
ZEB2-AS1 contributes to PE progression by inhibiting cell proliferative, migratory, invasive capacities and EMT via the miR-149/PGF axis in HTR-8/SVneo cells.
|
[156]
|
|
PRNCR1
|
placenta
|
upregulated
|
MAPK
|
Overexpression of LncRNA PRNCR1 in PE patients reduces the viability of cells, and is positively correlated with systolic blood pressure, diastolic blood pressure and urine protein
|
[157]
|
|
GHET1
|
placenta
|
downregulated
|
the E-cadherin / vimentin /fibronectin
|
GHET1 promotes PE by inhibiting cell proliferative, migratory, invasive capacities and EMT by stimulating E-cadherin and suppressing vimentin and fibronectin.
|
[158]
|
|
TDRG1
|
placenta
|
downregulated
|
miR-214-5p/Notch signaling pathway
|
TDRG1 inhibits cell viability, proliferation, migration, and invasion by stimulating the expression of miR-214-5p and regulating the Notch signaling pathway in trophoblast cells.
|
[159]
|
|
MALAT1
|
placenta
|
downregulated
|
pro-apoptotic proteins
|
Silencing of MALAT-1 in JEG-3 cells suppresses proliferation, migration and invasion, and induces cell cycle arrest at G0/G1 phase and enhancing apoptosis.
|
[160]
|
|
N-cadherin/vimentin /E-cadherin/Hu-antigen R (HuR) /FOS
|
Down-regulated MALAT1 inhibits trophoblast invasion, migration, epithelial mesenchymal transition (EMT) and spiral artery remodeling by upregulating E-cadherin and downregulating FOS, N-cadherin, and vimentin.
|
[161]
|
|
miR-206/IGF-1 axis
|
Down-regulated MALAT1 regulates miR-206/IGF-1 axis and thereby inhibits trophoblast cells migration and invasion through PI3K/Akt signal pathway.
|
[49]
|
|
TCL6
|
placenta
|
upregulated
|
PTEN/CDK2
|
Overexpression of lncRNA TCL6 is positively correlated with systolic blood pressure, diastolic blood pressure and urine protein, whereas negatively correlated with fetal birth weight of PE patients
|
[162]
|
|
uc003fir
|
placenta /preeclamptic placenta vessels/ vessel-free tissue
|
upregulated
|
CCL5/miR-155
|
Over-expression of lncRNA uc003fir increases proliferation, migration, and invasion of HTR-8/SVneo cells.
|
[163]
|
|
FOXD2-AS1
|
placenta
|
downregulated
|
miR-3127/MMP2/MMP9
|
FOXD2-AS1 silencing decreases the promotion effects on trophoblast cell induced by miR-3127 inhibition, partly mediated by influencing MMP2 and MMP9 levels.
|
[164]
|
|
KCNQ1OT1
|
placenta
|
downregulated
|
miR-146a-3p
|
KCNQ1OT1 could target the regulation of miR-146a-3p through CXCL12/CXCR4 pathway in the proliferation, invasion and migration of HTR8/SVneo cells.
|
[165]
|
|
SNHG5
|
placenta
|
downregulated
|
miR-26a-5p/N-cadherin
|
Knockdown of SNHG5 inhibits trophoblast (HTR-8/SVneo) cell proliferation, invasion, and migration, and promotes apoptosis and caused increase of cell population at the G 0 /G 1 phase and decrease of cell population at the S phase.
|
[166]
|
|
PVT1
|
placenta
|
downregulated
|
PI3K/AKT
|
PVT1 knockdown notably inhibits the proliferation, migration and invasiveness abilities of trophoblast cells, and significantly promotes the apoptosis through PI3K/AKT pathway.
|
[167]
|
|
Ezh2/ANGPTL4
|
PVT1 knockdown notably inhibits cell proliferation and stimulates cell cycle accumulation and apoptosis by repressing ANGPTL4 transcription through binding with EZH2 in trophoblast cell.
|
[168]
|
|
WDR86-AS1
|
placenta
|
upregulated
|
miR-10b-3p / LITAF
|
WDR86-AS1 downregulates miR-10b-3p but promotes LITAF expression, which controls the inflammatory responses and migration and proliferation of HTR-8/SVneo cells under hypoxia.
|
[169]
|
|
ATB
|
placenta
|
downregulated
|
/
|
Down-regulated lncRNA-ATB decreased migration, proliferation, tube-formation of HTR-8/SVneo cells.
|
[170]
|
|
RPAIN
|
placenta
|
upregulated
|
C1q
|
The increased RPAIN levels may contribute to the development of preeclampsia through regulating trophoblast proliferation, invasion and apoptosis via C1q.
|
[171]
|
|
NR_002794
|
placenta
|
upregulated
|
/
|
NR_002794 has suppressive effects on proliferation and migration, and results in an increased rate of apoptosis.
|
[172]
|
|
MVIH
|
placenta
|
downregulated
|
Jun-B
|
The silencing of MVIH expression inhibits cell growth, migration, invasion, and angiogenesis in various trophoblast cell lines by modulating Jun-B protein expression.
|
[173]
|
|
GASAL1
|
placenta
|
downregulated
|
SRSF1/mTOR/EBP1/Bcl-2/caspase-3
|
lncRNA GASAL1 interacts with SRSF1 to regulate the proliferative, invasive, and apoptotic abilities of trophoblast cells via the mTOR signaling pathway.
|
[174]
|
|
MIR193BHG
|
placenta
|
upregulated
|
/
|
/
|
[175]
|
|
PROX1-AS1
|
placenta
|
upregulated
|
/
|
/
|
|
GATA3-AS1
|
placenta
|
upregulated
|
/
|
/
|
|
00511
|
placenta
|
downregulated
|
miR-31-5p / HOXA7
|
Down-regulated lnc00511 suppresses proliferation, invasion and autophagy, and enhances apoptosis in trophoblast cells to mediate pre-eclampsia progression through modulating the miR-31-5p/homeobox protein A7 axis.
|
[176]
|
|
placenta
|
downregulated
|
miR-29b-3p/ Cyr61
|
AP2γ mediates downregulation of lncRNA LINC00511 as a ceRNA suppresses trophoblast invasion, proliferation and migration by regulating miR-29b-3p/Cyr61 axis.
|
[177]
|
|
AK002210
|
serum
|
downregulated
|
/
|
AK002210 knockdown suppresses trophoblast invasion, proliferation and migration
|
[178]
|
|
ZBTB39
|
placenta
|
upregulated
|
miR-210/THSD7A
|
Upregulated LncZBTB39 suppresses trophoblast invasion and migration via antagonizing the inhibition of miR-210 on THSD7A expression.
|
[179]
|
|
GAS5
|
placenta
|
upregulated
|
miR-21/MMP-9/TP53
|
GAS5 suppresses trophoblast invasion, proliferation and migration through the regulation of miR-21 and the activation of PI3K/AKT signaling pathway and its downstream proteins covering MMP-9 and TP53.
|
[180]
|
|
VIM-AS1
|
placenta
|
downregulated
|
E-cadherin/Snail/Vimentin
|
Down-regulated VIM-AS1 suppresses epithelial-to-mesenchymal transition (EMT) by upregulating E-cadherin and downregulating Snail and Vimentin.
|
[181]
|
|
FAM99A
|
placenta
|
downregulated
|
Wnt/β-catenin
|
Down-regulated FAM99A suppresses the invasive and migratory abilities of HTR-8/SVneo, and increases the apoptotic rate.
|
[182]
|
|
HIF1A-AS2
|
placenta
|
downregulated
|
LSD1/PHLDA1
|
HIF1A-AS2 suppresses trophoblast cell invasion and proliferation through upregulating PHLDA1 expression.
|
[183]
|
|
00261
|
placenta
|
upregulated
|
miR-558/TIMP4
|
Lnc00261 exerts the suppressive effects on the trophoblast invasion and migration via targeting miR-558/TIMP4 axis, which may involve in the pathogenesis of PE.
|
[184]
|
|
Uc.294
|
placenta
|
upregulated
|
/
|
Uc.294 inhibits proliferation, invasion and promotes apoptosis of trophoblast cells HTR-8/SVneo.
|
[185]
|
|
PSG10P
|
placenta
|
upregulated
|
miR-19a-3p/IL1RAP
|
IL1RAP promotes the expression of caspase-3 but inhibits MMP9 to suppresses proliferation, migration, and invasion of trophoblast cells.
|
[186]
|
|
00473
|
placenta
|
downregulated
|
LSD1/TFPI2
|
lnc00473 inhibits the expression of tissue factor pathway inhibitor 2 (TFPI2) through binding to lysine-specific demethylase 1 (LSD1) to inhibits cell proliferation and promotes apoptosis.
|
[187]
|
|
Uc.187
|
placenta
|
upregulated
|
PCNA and Ki67/MMP-2/−9 / TIMP-1/ Bcl-2
|
Uc.187 suppresses cell proliferation and invasion and promotes the cellular apoptotic response
|
[188]
|
