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Table 1 Characteristics of the patients and the IVF cycle that gave rise to miscarriage conception in the different management groups

From: Endometrial thickness following early miscarriage in IVF patients – is there a preferred management approach?

Parameter

Conservative management

Misoprostol

D&C

P value

N of patients

78

61

84

 

Age (years)

34.6 ± 6.6(35(29–41))

37.1 ± 5.0(39(33–41))

35.7 ± 5.6(37(31–40))

0.06

BMI

25.8 ± 2.8(25(23–28))

24.3 ± 6.1(23(19–30))

26.7 ± 7.8(24(21–30))

0.61

Obstetric background

Gravidity

1.3 ± 1.5(1(0–2))

1.8 ± 2.2(1(0–3))

1.8 ± 1.8(2(2–3))

0.16

Past deliveries

28/72 (38.9%)

27/59 (45.8%)

49/81 (59.3%)

0.04

Prior miscarriages

0.8 ± 1.2(0(0–1))

1.1 ± 1.8(1(0–2))

0.9 ± 1.4(0(0–1))

0.41

Patients with a previous D&C

17.9%

25.5%

19.7%

0.83

Infertility (years)

4.1 ± 4.8(3(1–5))

2.6 ± 1.8(2(1–4))

4.2 ± 3.3(3(2–6))

0.08

Day 3 FSH levelsa (mIU/ml)

7.7 ± 6.9(6(5–9))

8.4 ± 7.5(7(6–9))

6.9 ± 3.1(7(5–8))

0.41

Miscarriage cycle

Peak E2 levels (Fresh cycles, pmol/l)

6146.2 ± 3939.9(5477(2896–8593))

5910.9 ± 3464.5(4942(3928–7866)

6267.3.5 ± 4273.0(5654(3547–8104))

0.53

Endometrium (mm) at hCG/LH/P

9.9 ± 1.8(10(9–12))

10.1 ± 2.0(10(9–11))

10.1 ± 2.1(10(9–12))

0.81

> 1 embryonal sac

8(10.5%)

3(4.9%)

7(7.7%)

0.48

Week of miscarriage

6.7 ± 1.3(6(6–7))

7.7 ± 1.3(7(7–9))

8.6 ± 1.6(8(8–10))

< 0.001b

Hysteroscopy for retained placenta

3(4.2%)

1(1.8%)

0

0.13

  1. Data presented as mean ± SD (Median (IQR)) or n (%)
  2. Statistical analysis was performed using the Pearson Chi-Square test or Fisher’s Exact Test as indicated for categorical data and ANOVA or Kruskal-Wallis test (for variables with unequal distribution) for continuous parameters
  3. Note: BMI Body mass index, D&C Dilation and curettage, FSH Follicular stimulating hormone, hCG/LH/P Day of human chorionic gonadotropin administration in fresh IVF cycles, luteinizing hormone surge or progesterone administration in frozen-thawed cycles
  4. aBaseline FSH levels measured in hormone panel test at day three of menstrual period (prior to initiation of hormonal therapy)
  5. bPost hoc Dunnett T3 test showed significant difference between all the study groups