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Fig. 4 | Reproductive Biology and Endocrinology

Fig. 4

From: Downregulation of decidual SKP2 is associated with human recurrent miscarriage

Fig. 4

SKP2 silencing attenuates decidualization through downregulation of GLUT1 expression during induced decidualization. A, B HESCs transfected with scramble siRNA or siSKP2 were incubated in induction medium for four days. Both mRNA and protein expression of GLUT1 were reduced after knockdown of SKP2. C, D GLUT1 silencing attenuated decidualization. Knockdown of GLUT1 in HESCs transfected with control siRNA or siGLUT1 was determined by western blot analysis. mRNA expression of GLUT1, IGFBP1, and PRL was determined by qPCR. All data are shown as the mean ± SEM. *P < 0.05; **P < 0.01. ***P < 0.001

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