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Fig. 3 | Reproductive Biology and Endocrinology

Fig. 3

From: Downregulation of decidual SKP2 is associated with human recurrent miscarriage

Fig. 3

SKP2 is up-regulated during decidualization and its regulatory function in human decidualization. A The levels of SKP2 mRNA was up-regulated in HESCs after the induction of decidualization. Decidualization was induced by the addition of MPA and db-cAMP for 4 days. B The expression of SKP2 was analyzed by qPCR between decidualized stromal cells (DSCs) from first trimester pregnancy (n = 10) and endometrial stromal cells (ESCs) from proliferative endometria (n = 6). C Decidualization of HESCs was induced by the addition of MPA and db-cAMP for 4 days. The expression of the transcription factors HOXA10 and FOXM1 during decidualization was detected by qPCR. The levels of HOXA10 and FOXM1 mRNA were downregulated in HESCs during induced decidualization after SKP2 knockdown. Data are shown as the mean ± SEM. *P < 0.05; **P < 0.01

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