Fig. 2
From: Downregulation of decidual SKP2 is associated with human recurrent miscarriage
Effects of silencing SKP2 on human decidualization. A SKP2 knockdown caused impaired decidualization of HESCs. Decidualization markers (IGFBP1 and PRL) decreased in HESCs, in which decidualization was induced for 4 days after transfection with siSKP2 for 24 h. B The influence of SKP2 knockdown on the decidualization of primary human ESCs. Decidualization was induced in primary human ESCs for 4 days after transfection with NC or siSKP2. C The influence of SKP2 knockdown on the cell morphology of HESCs after decidualization induction. Decidualization was induced with MPA and db-cAMP after transfection with NC or siSKP2 for 24 h. HESCs (human endometrial stromal cells); ESCs (endometrial stromal cells); NC, scramble siRNA; siSKP2, siRNA against SKP2. All data are shown as the mean ± SEM. *P < 0.05; **P < 0.01