Table 2 Treatment-related characteristics of the unweighted population, for stimulation cycles (fresh only)
|  | r-hFSH-alfa N = 23,429 | hMG HP N = 14,805 | Difference (95% CI) |
|---|---|---|---|
GnRH protocol, n (%) | |||
 Agonist | 17,434 (74.4) | 12,031 (81.3) | 6.85 (6.01, 7.69) |
  Long | 15,438 (65.9) | 7845 (53.0) | −12.90 (− 13.91, − 11.90) |
  Short | 1670 (7.1) | 4007 (27.1) | 19.94 (19.15, 20.73) |
  Ultralong | 279 (1.2) | 143 (1.0) | − 0.22 (− 0.43, − 0.01) |
  Ultrashort | 47 (0.2) | 36 (0.2) | 0.04 (−0.06, 0.14) |
 Antagonist | 5995 (25.6) | 2774 (18.7) | −6.85 (−7.69, −6.01) |
  Multiple | 3834 (16.4) | 2010 (13.6) | −2.79 (−3.52, −2.06) |
  Single | 2161 (9.2) | 764 (5.2) | −4.06 (−4.58, − 3.55) |
Mean (SD) number of oocytes retrieved | 10.3 (6.2) | 8.2 (5.8) | −2.02 (− 2.15, −1.90) |
Mean (SD) number of embryos transferred | 1.9 (0.7) | 1.8 (0.8) | −0.05 (−0.06, −0.03) |
Mean (SD) number of 2PN cryopreserved | 2.1 (3.4) | 1.2 (2.6) | −0.84 (− 0.90, − 0.78) |
ART treatment, n (%) | |||
 ICSI | 17,013 (72.6) | 9471 (64.0) | −8.64 (−9.60, −7.68) |
 IVF | 5436 (23.2) | 4605 (31.1) | 7.90 (6.98, 8.82) |
 IVF, ICSI | 611 (2.6) | 190 (1.3) | −1.32 (−1.60, −1.05) |
 Not planned | 369 (1.6) | 539 (3.6) | 2.07 (1.72, 2.41) |
Mean (SD) OSI (oocytes per 1000 IU) | 10.8 (16.0) | 7.7 (22.1) | −3.05 (−3.46, −2.64) |
Drug used to trigger ovulation, n (%) | |||
 r-hCG | 13,164 (57.4) | 5579 (39.1) | −18.29 (−19.31, −17.26) |
 Triptorelin | 37 (0.2) | 7 (0.1) | −0.11 (−0.18, −0.05) |
 u-hCG | 9694 (42.3) | 8612 (60.4) | 18.10 (17.07, 19.12) |
 Other | 43 (0.2) | 70 (0.5) | 0.30 (0.18, 0.43) |
Drug used for luteal support, n (%) | |||
 Progestogens | 12,113 (51.7) | 6167 (41.7) | −10.05 (−11.07, −9.03) |
 Estrogen | 5 (0.0) | 9 (0.1) | 0.04 (0.00, 0.08) |
 hCG | 217 (0.9) | 362 (2.5) | 1.52 (1.24, 1.80) |
 Data not available | 2732 (11.7) | 2969 (20.1) | 8.39 (7.63, 9.16) |
 Other | 26 (0.1) | 6 (0.0) | −0.07 (−0.12, −0.02) |
 Progestogens and estrogen | 3367 (14.4) | 1675 (11.3) | −3.06 (−3.74, −2.38) |
 Progestogens and hCG | 4421 (18.9) | 3150 (21.3) | 2.41 (1.58, 3.23) |
 Progestogens, estrogen and hCG | 548 (2.3) | 467 (3.2) | 0.82 (0.47, 1.16) |
Mean (SD) duration of COS, days | 10.8 (2.4) | 10.8 (2.6) | −0.01 (−0.07, 0.04) |
Mean (SD) total drug usage (IU) | 1546.3 (875.4) | 2147.0 (1330.7) | 600.74 (576.55, 624.93) |
Mean (SD) total drug usage per oocyte retrieved (IU) | 236.0 (332.2) | 455.4 (687.0) | 219.43 (207.58, 231.29) |