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Table 2 Embryo characteristics for each maternal age group

From: Comparing prediction of ongoing pregnancy and live birth outcomes in patients with advanced and younger maternal age patients using KIDScore™ day 5: a large-cohort retrospective study with single vitrified-warmed blastocyst transfer

  <  35 35–37 38–40 41–42 ≥ 43 Total
tPNf (hour) 22.8 ± 0.17 22.8 ± 0.16 22.7 ± 0.12 22.7 ± 0.13 22.5 ± 0.12 22.7 ± 0.06
t2 (hour) 25.4 ± 0.18 25.4 ± 0.16 25.2 ± 0.13 25.2 ± 0.13 25.1 ± 0.12 25.2 ± 0.06
t3 (hour) 35.4 ± 0.24 35.7 ± 0.22 35.4 ± 0.18 35.6 ± 0.19 35.4 ± 0.16 35.5 ± 0.09
t4 (hour) 37.0 ± 0.27 37.2 ± 0.23 37.0 ± 0.19 36.9 ± 0.21 37.0 ± 0.18 37.0 ± 0.09
t5 (hour) 48.2 ± 0.42 48.3 ± 0.36 48.3 ± 0.29 48.3 ± 0.32 48.4 ± 0.27 48.3 ± 0.14
tB (hour) 104.7 ± 0.61 a 105.6 ± 0.52 ab 106.2 ± 0.42 b 106.9 ± 0.47 b 108.9 ± 0.40 c 106.8 ± 0.21
Day of cryopreservation
(%)
Day 5* 76.7 73.3 71.8 70.0 60.1 69.0
Day 6* 22.6 25.2 27.1 28.4 37.8 29.5
Day 7* 0.7 1.5 1.1 1.6 2.1 1.5
ICM grade
(%)
A* 58.9 53.3 53.5 50.6 40.3 49.8
B 24.3 25.4 25.9 28.6 26.7 26.4
C* 16.8 21.2 20.6 20.8 33.3 23.8
TE grade
(%)
A* 55.8 46.2 44.2 39.2 28.3 40.5
B 20.9 24.2 26.3 25.7 22.7 24.2
C* 23.3 29.6 29.5 35.1 49.0 35.3
KIDScore Average 6.68 ± 2.33 a 6.35 ± 2.47 ab 6.23 ± 2.40 bc 6.02 ± 2.39 cd 5.28 ± 2.33 e 6.0 ± 2.4
MAX 9.8 9.8 9.8 9.8 9.8 9.8
75% 8.6 8.6 8.4 8.1 7.3 8.2
Median 7.4 6.9 6.7 6.4 5.1 6.3
25% 2.9 2.6 2.6 2.6 2.4 3.7
MIN 1.7 1.4 1.4 1.5 1.3 1.3
  1. Value are mean ± SEM or %
  2. Different subscripts are statistically significant different across the maternal age groups (P <  0.05)
  3. * An asterisk means significant correlation between the rates of each grade and maternal age groups by Cochran-Armitage trend test (P <  0.05). Timing of pronuclear fading = tPNf); Timing of 2-cell division = t2; Timing of 3-cell division = t3; Timing of 4-cell division = t4; Timing of 5-cell division = t5; Timing of blastocyst formation = tB; SEM Standard error of the means, ICM Inner cell mass, TE Trophectoderm