Fig. 1

Quantitative analysis of proteomics data between control group and obese subjects. a Scatter plot showing the principle component analysis clustering of subjects. Each dot represents a subject and is colored according to subject groups indicated in the bottom-right corner of the plot. b Scatter plot showing the t-distributed stochastic neighbor embedding clustering of subjects. c Volcano plot of differentially expressed proteins (DEPs). The x-axis corresponds to the log2-transformed fold change of DEPs identified when comparing obese group (OB) versus control group (CTR). The y-axis corresponds to -log10-transformed P values. Upregulated and downregulated DEPs are colored in red and blue, respectively. The top 10 upregulated and downregulated DEPs are labeled. d Heatmap showing the hierarchical clustering of samples and DEPs. Samples of the OB and CTR groups are colored in red and blue, respectively