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Fig. 6 | Reproductive Biology and Endocrinology

Fig. 6

From: Upregulated Talin1 synergistically boosts β-estradiol-induced proliferation and pro-angiogenesis of eutopic and ectopic endometrial stromal cells in adenomyosis

Fig. 6

Additive effects of Talin1 on β-E2 promoted the growth and angiogenesis of hypodermic endometrial lesions in nude mice. a. Ovariectomized female BALB/c nude mice were xenografted with IshikawaER+ cells which were pretreated with β-E2 or OV-Talin1 or both or neither. And the mice were randomly divided into four groups: OV-NC, OV-Talin1, β-E2, β-E2 + OV-Talin1. b. Photographs of lesions were taken on the 84th day after inoculating cells into the axilla of mice. c and d. Lesion growth curves and excised lesion weights were recorded and quantitatively analyzed. e-g Protein and mRNA levels of molecular markers related to cell proliferation and angiogenesis in hypodermic endometrial lesions. Data were presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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