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Table 2 Reproductive outcomes of all patients (n = 255) and of each group: women with normo-androgenic PCOS (n = 110) and without PCOS having normal ovarian reserve (NOR) (n = 145)

From: Extracellular microRNAs: key players to explore the outcomes of in vitro fertilization

Reproductive outcomes

Total No. of Participants (n = 255)

Women with NOR (n = 145)

Women with normo-androgenic PCOS (n = 110)

Mann-Whitney test P-value

Ovarian outcome parameters

 No. of Follicles aspirated [median (95% population limit)]

16.20 (11.2; 20.6)

13 (10.3; 18.2)

17 (15.4; 25.6)

0.03

 No. of oocytes Retrieved [median (95% population limit)]

13.02 (10.32; 18.3)

11 (8.2; 13.5)

14.6 (11.3; 20.8)

0.001

 No. of MII- oocytes [median (95% population limit)]

9.81 (8.01; 13.8)

9.4 (7.9; 12.3)

10.5 (8.7; 15.8)

0.04

 Rate of mature oocytes (%) (0–100)

80

84

76

0.001

 No. of Fertilized oocytes [median (95% population limit)]

9.10 (7.2; 11.98)

8.91 (6.4; 11.3)

9.86 (7.7; 13.54)

0.04

 Fertilization rate (mean ± SD)

6.01 ± 1.68

4.92 ± 1.96

8.65 ± 1.33

0.001

Embryological outcome parameters

 No. of Normal Fertilized oocytes (2PN) [median (95% population limit)]

8.21 (6.01; 10.2)

8.41 (5.9; 10.6)

8.03 (6.7; 10.55)

0.09

 No. of Early cleaved zygotes [median (95% population limit)]

8.00 (5.01; 8.51)

8.01 (5.2; 9.97)

7.99 (4.5; 9.69)

0.71

 No. of blastomeres (6–8 cells) with regular symmetry at day 3 median (95% population limit)]

7.01 (4.89; 8.74)

7.22 (4.87; 8.14)

7.19 (4.96; 9.01)

0.66

 No. of High-Quality day 3 embryos [median (95% population limit)]

2.00 (1.05; 3.01)

2.10 (1.98; 3.21)

2.20 (2.01; 2.99)

0.73

 Total fragmentation rate (%)

15

13

18

0.001

 Blastulation rate (%) at day 5 (0–100)

43

48

36

0.001

 Expended blastocyst rate (%) at day 5 (0–100)

46

49

37

0.001

Clinical outcomes

 Clinical pregnancy rate per transfer (%) (0–100)

35

39

26

0.001

  1. The values are presented as median (95% population limit) and percentage (%) point scale (0–100). P-value (Mann-Whitney test) < 0.05 considered statistically significant. Blastocyst rate was based on the number of blastocysts obtained / the number of zygotes cleaved. The number of fertilized oocytes means the total number of oocytes that were fertilized. A number of normally fertilized oocytes mean total fertilized oocytes obtained / abnormally fertilized oocytes. The fertilization rate is based on the number of oocytes obtained / the number of zygotes cleaved