From: Extracellular microRNAs: key players to explore the outcomes of in vitro fertilization
Reproductive outcomes | Total No. of Participants (n = 255) | Women with NOR (n = 145) | Women with normo-androgenic PCOS (n = 110) | Mann-Whitney test P-value |
---|---|---|---|---|
Ovarian outcome parameters | ||||
No. of Follicles aspirated [median (95% population limit)] | 16.20 (11.2; 20.6) | 13 (10.3; 18.2) | 17 (15.4; 25.6) | 0.03 |
No. of oocytes Retrieved [median (95% population limit)] | 13.02 (10.32; 18.3) | 11 (8.2; 13.5) | 14.6 (11.3; 20.8) | 0.001 |
No. of MII- oocytes [median (95% population limit)] | 9.81 (8.01; 13.8) | 9.4 (7.9; 12.3) | 10.5 (8.7; 15.8) | 0.04 |
Rate of mature oocytes (%) (0–100) | 80 | 84 | 76 | 0.001 |
No. of Fertilized oocytes [median (95% population limit)] | 9.10 (7.2; 11.98) | 8.91 (6.4; 11.3) | 9.86 (7.7; 13.54) | 0.04 |
Fertilization rate (mean ± SD) | 6.01 ± 1.68 | 4.92 ± 1.96 | 8.65 ± 1.33 | 0.001 |
Embryological outcome parameters | ||||
No. of Normal Fertilized oocytes (2PN) [median (95% population limit)] | 8.21 (6.01; 10.2) | 8.41 (5.9; 10.6) | 8.03 (6.7; 10.55) | 0.09 |
No. of Early cleaved zygotes [median (95% population limit)] | 8.00 (5.01; 8.51) | 8.01 (5.2; 9.97) | 7.99 (4.5; 9.69) | 0.71 |
No. of blastomeres (6–8 cells) with regular symmetry at day 3 median (95% population limit)] | 7.01 (4.89; 8.74) | 7.22 (4.87; 8.14) | 7.19 (4.96; 9.01) | 0.66 |
No. of High-Quality day 3 embryos [median (95% population limit)] | 2.00 (1.05; 3.01) | 2.10 (1.98; 3.21) | 2.20 (2.01; 2.99) | 0.73 |
Total fragmentation rate (%) | 15 | 13 | 18 | 0.001 |
Blastulation rate (%) at day 5 (0–100) | 43 | 48 | 36 | 0.001 |
Expended blastocyst rate (%) at day 5 (0–100) | 46 | 49 | 37 | 0.001 |
Clinical outcomes | ||||
Clinical pregnancy rate per transfer (%) (0–100) | 35 | 39 | 26 | 0.001 |