Fig. 3
From: Extracellular microRNAs: key players to explore the outcomes of in vitro fertilization
a Comparative expression profile of FF miR-202-5p and FF miR-378-3p in NOR patients relative to the gonadotropin type. rFSH (n = 80) (recombinant follicle-stimulating hormone), HP-hMG (n = 65) (highly purified human menopausal gonadotropin (Mann-Whitney test, p = 0.001). b Expression profile of FF miR-202-5p in NOR patients relative to the total dose of gonadotropin (≥ 3000, n = 90, ≤ 3000, n = 55) Mann-Whitney test, p = 0.001. c The relative expression of FF miR-202-5p has a significant but positive correlation with the overall dosage of gonadotropins (R2 = 0.669, p = 0.001). d Differential expression of FF miR-378-3p and FF miR-224 in NOR patients according to the number of retrieved oocytes on day 3 (≥ 3, n = 125, ≤ 3, n = 20) Mann-Whitney test, p = 0.001. e Spearman correlation coefficient depicted a significant positive association between FF miR-378-3p and the number of mature oocytes in NOR patients (n = 145). f The relative expression of FF miR-224 has a significant positive correlation with the number of mature oocytes in NOR patients. g Relative expression profile of FF miR-320a in NOR patients between top-quality embryos and non-top-quality embryos (Mann-Whitney test, p = 0.001). h The receiver operating characteristic (ROC) curve showing the discriminative capability of the FF miR-320a expression profile to predict embryo quality in NOR patients (n = 145)