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Fig. 4 | Reproductive Biology and Endocrinology

Fig. 4

From: Quercetin prevents primordial follicle loss via suppression of PI3K/Akt/Foxo3a pathway activation in cyclophosphamide-treated mice

Fig. 4

Quercetin inhibits overactivation of dormant PMFs induced by Cy. In normal circumstances, the dormancy or activation of primordial follicles was regulated by PI3K signalling pathway and the inhibitor factors secreted by growing follicles, such as AMH. Cyclophosphamide disrupts the balance of the PI3K signalling pathway and decreases AMH level by inducing apoptosis in growing follicles, resulting in the overactivation of the primordial follicles and the burnout of the reserve. Coadministration of quercetin and Cy prevents the phosphorylation of PI3K/Akt/Foxo3a pathway members and maintains AMH level through reduced apoptosis in growing follicles to restore the ovary to a state of equilibrium

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