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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Quercetin prevents primordial follicle loss via suppression of PI3K/Akt/Foxo3a pathway activation in cyclophosphamide-treated mice

Fig. 2

Quercetin prevents apoptosis in growing follicles and decreases AMH induced by Cy. a-b Representative images of mouse ovaries stained with TUNEL (a) and cleaved caspase-3 antibody (b) are shown for each treatment condition. Bars represent 50 μm. c TUNEL-based quantification of the apoptotic index per follicle class calculated as the fraction of apoptotic/total follicles for each type (n = 5 mice/group, *P < 0.05, **P < 0.01, compared with the Cy group; ## P < 0.01 compared with the control group). Primordial follicles did not present TUNEL-positive cells in any experimental group. One-way ANOVA followed by Tukey’s tests was used for comparisons. d AMH plasma concentrations were measured at 24 h after administration of PBS or Cy with or without quercetin (n = 5 mice/group). Data represent the means ± SEM. One-way ANOVA followed by Tukey’s tests was used for comparisons (***P < 0.001 compared with the Cy group)

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