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Table 1 Characteristics of pre-HDP patients and healthy pregnancies

From: Serum complement proteomics reveal biomarkers for hypertension disorder of pregnancy and the potential role of Clusterin

Factors The screening and validation set
Control (n = 148) Pre-HDP (n = 148) P
N (%) N (%)
Demographic characteristics
 Han nationality, n (%) 145 (97.97) 145 (97.97) 1.00
 Maternal age (years) 30.84 ± 4.46 30.99 ± 4.69 0.83
 Weight (kg) 64.71 ± 9.16 72.12 ± 11.44 < 0.001
 BMI (kg/m2) 25.37 ± 2.47 28.49 ± 3.98 < 0.001
 Diastolic (≤ 20 wk) 73.54 ± 12.94 87.9 ± 12.96 < 0.001
 Systolic (≤ 20 wk) 117.4 ± 17.63 138.39 ± 15.60 < 0.001
 GA at sample collection 14.27 ± 4.80 14.36 ± 4.64 0.917
 GA at delivery 39.02 ± 0.95 37.45 ± 2.39 < 0.001
Medical history
 Anaemia n (%) 14 (10.22) 24 (18.46) 0.054
 Family history of DM, n (%) 2 (1.47) 6 (4.35) 0.16
 Family history of HDP, n (%) 1 (0.74) 2 (1.45) 0.57
Past obstetric history
 Gravidity ≥2, n (%) 93 (62.84) 95 (64.19) 0.81
 History of term delivery ≥1, n (%) 117 (79.05) 106 (71.62) 0.14
 Spontaneous miscarriage ≥1, n (%) 21 (14.19) 26 (17.57) 0.43
  1. GA gestational age, BMI body mass index, DBP diastolic blood pressure, SBP systolic blood pressure, DM diabetes disease, HDP hypertension disorder of pregnancy. Data are presented as the mean ± SD (standard deviation) and analysed by Student’s t-test. Data are presented as n (%) and were analysed using a chi-square test or Fisher’s exact test. Women who developed HDP and women who had a healthy pregnancy were matched by age and gestational week
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