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Table 1 Characteristics of pre-HDP patients and healthy pregnancies

From: Serum complement proteomics reveal biomarkers for hypertension disorder of pregnancy and the potential role of Clusterin

Factors

The screening and validation set

Control (n = 148)

Pre-HDP (n = 148)

P

N (%)

N (%)

Demographic characteristics

 Han nationality, n (%)

145 (97.97)

145 (97.97)

1.00

 Maternal age (years)

30.84 ± 4.46

30.99 ± 4.69

0.83

 Weight (kg)

64.71 ± 9.16

72.12 ± 11.44

< 0.001

 BMI (kg/m2)

25.37 ± 2.47

28.49 ± 3.98

< 0.001

 Diastolic (≤ 20 wk)

73.54 ± 12.94

87.9 ± 12.96

< 0.001

 Systolic (≤ 20 wk)

117.4 ± 17.63

138.39 ± 15.60

< 0.001

 GA at sample collection

14.27 ± 4.80

14.36 ± 4.64

0.917

 GA at delivery

39.02 ± 0.95

37.45 ± 2.39

< 0.001

Medical history

 Anaemia n (%)

14 (10.22)

24 (18.46)

0.054

 Family history of DM, n (%)

2 (1.47)

6 (4.35)

0.16

 Family history of HDP, n (%)

1 (0.74)

2 (1.45)

0.57

Past obstetric history

 Gravidity ≥2, n (%)

93 (62.84)

95 (64.19)

0.81

 History of term delivery ≥1, n (%)

117 (79.05)

106 (71.62)

0.14

 Spontaneous miscarriage ≥1, n (%)

21 (14.19)

26 (17.57)

0.43

  1. GA gestational age, BMI body mass index, DBP diastolic blood pressure, SBP systolic blood pressure, DM diabetes disease, HDP hypertension disorder of pregnancy. Data are presented as the mean ± SD (standard deviation) and analysed by Student’s t-test. Data are presented as n (%) and were analysed using a chi-square test or Fisher’s exact test. Women who developed HDP and women who had a healthy pregnancy were matched by age and gestational week