Fig. 4

a-c, ELISA analysis of serum levels of CLU, CFHR5, and CRP before 20 weeks gestation in women who experienced an uncomplicated pregnancy and women who later developed HDP (88 HDP and 88 normal pregnancy cases). b, Serum levels of CLU, CFHR5, and CRP in GH and normal pregnancies (n = 22). c, Serum levels of CLU, CFHR5, and CRP in PE and normal pregnancies (n = 26). Data are presented as the mean ± SD and were analysed with a paired t-test. d-f, ROC curve of HDP prediction. d, ROC curve of HDP prediction. e, ROC curve of GH prediction. f, ROC curve of PE prediction. The area under the curve (AUC) for each curve is listed in the lower right corner. *P < 0.05, **P < 0.01, ***P < 0.001