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Table 3 Univariate and multivariate analysis of predictor variables for HDP

From: Thin endometrium is associated with the risk of hypertensive disorders of pregnancy in fresh IVF/ICSI embryo transfer cycles: a retrospective cohort study of 9,266 singleton births

Predictor variable

OR (95% CI)

P value

aOR (95% CI)

P value

EMT on HCG trigger day (mm)

  ≤ 8

1.958 (1.367–2.805)

< 0.001a

1.853 (1.281–2.679)

0.001a

  > 8–12

1

 

1

 

  > 12

0.984 (0.765–1.265)

0.898

1.000 (0.775–1.291)

0.999

Parity

 First

1

 

1

 

 High order

1.007 (0.783–1.295)

0.955

0.774 (0.550–1.088)

0.141

ART treatment typy

 IVF

1

 

1

 

 ICSI

0.923 (0.725–1.174)

0.514

0.961 (0.751–1.229)

0.751

Ovarian stimulation protocol

 GnRH antagonist protocol

1

 

1

 

 GnRH agonist long protocol

1.004 (0.740–1.362)

0.981

1.071 (0.784–1.463)

0.667

 GnRH agonist short protocol

1.346 (0.967–1.875)

0.078

1.205 (0.848–1.712)

0.298

 GnRH agonist super long protocol

1.319 (0.776–2.243)

0.306

1.184 (0.688–2.037)

0.542

Other protocol

1.318 (0.402–4.323)

0.648

0.878 (0.259–2.969)

0.834

Type of infertility

 Primary

1

 

1

 

 Secondary

1.155 (0.932–1.433)

0.188

1.034 (0.798–1.340)

0.799

Number of embryos transferred

 1

1

 

1

 

 2

0.828 (0.663–1.036)

0.099

0.738 (0.503–1.084)

0.121

Stage of embryo transferred

 Cleavage-stage transfer

1

 

1

 

 Blastocyst transfer

1.089 (0.857–1.384)

0.485

0.938 (0.762–1.154)

0.542

Previous cesarean section

 No

1

 

1

 

 Yes

0.577 (0.357–0.933)

0.025a

0.471 (0.275–0.804)

0.006a

Endometriosis

 No

1

 

1

 

 Yes

0.218 (0.030–1.565)

0.13

0.213 (0.029–1.545)

0.126

PCOS

 No

1

 

1

 

 Yes

1.195 (0.886–1.611)

0.243

1.031 (0.749–1.419)

0.853

  1. ART assisted reproductive technology, IVF in vitro fertilization, ICSI intracytoplasmic sperm injection, EMT endometrial thickness, HCG human chorionic gonadotropin, GDM gestational diabetes mellitus, GnRH gonadotropin-releasing hormone, PCOS polycystic ovary syndrome, OR odds ratio, CI confidence interval, aOR adjusted odds ratio
  2. For variables of age, BMI, estradiol and progesterone level on HCG administration day, restricted cubic splines were generated to adjust for the non-linear relationship between these continuous variables and HDP. Thus, quantitative results were not presented
  3. a P < 0.05