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Table 4 Year-based subgroup analysis of patient characteristics and pregnancy outcomes in the first IUI cycle

From: Controlled ovarian stimulation should not be preferred for male infertility treated with intrauterine insemination: a retrospective study

Characteristics Before 2014 From 2014 onwards
NC-IUI COS-IUI P -value NC-IUI COS-IUI P -value
n 111 21   146 29  
Female age (years) 30.9 ± 5.1 29.5 ± 3.7 0.245 31.5 ± 4.6 30.0 ± 4.8 0.074
Male age (years) 33.2 ± 5.8 32.8 ± 4.6 0.356 33.4 ± 5.2 33.3 ± 5.8 0.845
Type of infertility (n (%))    1.000    0.683
 Primary 80 (72.1) 15 (71.4)   83(56.8) 18(62.1)  
 Secondary 31(27.9) 6 (28.6)   63(43.2) 11(37.9)  
Duration of infertility (years) 2.9 ± 1.9 3.5 ± 2.5 0.447 2.8 ± 1.7 2.6 ± 2.4 0.189
No. of dominant follicles ≥16 mm 1.0 ± 0.0 1.5 ± 0.5 0.000 1.0 ± 0.1 1.4 ± 0.5 0.000*
Endometrium thickness (mm) 10.3 ± 1.5 10.0 ± 1.6 0.488 9.7 ± 1.4 9.5 ± 1.7 0.534
TPMSC (×106)
 pre-wash 71.6 ± 89.9 58.8 ± 54.4 0.661 47.5 ± 36.7 48.2 ± 33.5 0.804
 post-wash 20.4 ± 15.8 16.9 ± 10.0 0.597 16.5 ± 10.6 18.4 ± 12.8 0.696
Normal morphology (%)
 pre-wash 6.0 ± 1.6 5.7 ± 1.8 0.977 3.0 ± 1.2 3.3 ± 1.2 0.203
 post-wash 8.2 ± 1.9 7.5 ± 1.7 0.633 4.7 ± 1.5 4.8 ± 1.4 0.508
 Clinical pregnancy (n (%)) 13 (11.7) 2(9.5) 1.000 19(13.0) 5(17.2) 0.557
 Live birth (n (%)) 10(9.0) 2(9.5) 1.000 18(12.3) 4(13.8) 0.765
Spontaneous abortion (n (%)) 1(7.7) 0 1.000 1(5.3) 1(20.0) 0.380
Ectopic pregnancy (n (%)) 2(15.4) 0 1.000 0 0
Multiple pregnancy (n (%)) 0 0 0 0
  1. IUI Intrauterine insemination, NC Natural cycle, COS Controlled ovarian stimulation, TPMSC Total progressive motile sperm count; * denotes a statistically significant difference (P < 0.05)