Table 4 Year-based subgroup analysis of patient characteristics and pregnancy outcomes in the first IUI cycle
Characteristics | Before 2014 | From 2014 onwards | ||||
|---|---|---|---|---|---|---|
NC-IUI | COS-IUI | P -value | NC-IUI | COS-IUI | P -value | |
n | 111 | 21 | 146 | 29 | ||
Female age (years) | 30.9 ± 5.1 | 29.5 ± 3.7 | 0.245 | 31.5 ± 4.6 | 30.0 ± 4.8 | 0.074 |
Male age (years) | 33.2 ± 5.8 | 32.8 ± 4.6 | 0.356 | 33.4 ± 5.2 | 33.3 ± 5.8 | 0.845 |
Type of infertility (n (%)) | 1.000 | 0.683 | ||||
Primary | 80 (72.1) | 15 (71.4) | 83(56.8) | 18(62.1) | ||
Secondary | 31(27.9) | 6 (28.6) | 63(43.2) | 11(37.9) | ||
Duration of infertility (years) | 2.9 ± 1.9 | 3.5 ± 2.5 | 0.447 | 2.8 ± 1.7 | 2.6 ± 2.4 | 0.189 |
No. of dominant follicles ≥16 mm | 1.0 ± 0.0 | 1.5 ± 0.5 | 0.000 | 1.0 ± 0.1 | 1.4 ± 0.5 | 0.000* |
Endometrium thickness (mm) | 10.3 ± 1.5 | 10.0 ± 1.6 | 0.488 | 9.7 ± 1.4 | 9.5 ± 1.7 | 0.534 |
TPMSC (×106) | ||||||
pre-wash | 71.6 ± 89.9 | 58.8 ± 54.4 | 0.661 | 47.5 ± 36.7 | 48.2 ± 33.5 | 0.804 |
post-wash | 20.4 ± 15.8 | 16.9 ± 10.0 | 0.597 | 16.5 ± 10.6 | 18.4 ± 12.8 | 0.696 |
Normal morphology (%) | ||||||
pre-wash | 6.0 ± 1.6 | 5.7 ± 1.8 | 0.977 | 3.0 ± 1.2 | 3.3 ± 1.2 | 0.203 |
post-wash | 8.2 ± 1.9 | 7.5 ± 1.7 | 0.633 | 4.7 ± 1.5 | 4.8 ± 1.4 | 0.508 |
Clinical pregnancy (n (%)) | 13 (11.7) | 2(9.5) | 1.000 | 19(13.0) | 5(17.2) | 0.557 |
Live birth (n (%)) | 10(9.0) | 2(9.5) | 1.000 | 18(12.3) | 4(13.8) | 0.765 |
Spontaneous abortion (n (%)) | 1(7.7) | 0 | 1.000 | 1(5.3) | 1(20.0) | 0.380 |
Ectopic pregnancy (n (%)) | 2(15.4) | 0 | 1.000 | 0 | 0 | – |
Multiple pregnancy (n (%)) | 0 | 0 | – | 0 | 0 | – |