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Fig. 4 | Reproductive Biology and Endocrinology

Fig. 4

From: Hsp90 modulates human sperm capacitation via the Erk1/2 and p38 MAPK signaling pathways

Fig. 4

17-AAG affects total and phosphorylated Erk1/2 (p-Erk1/2) expression during human sperm capacitation. a. The effects of 17-AAG on p-Erk1/2 and Ekr1/2 were determined by western blotting. b. The densitometric ratio of p-Erk1/2 to Erk1/2. No significant difference was observed between the different groups. Data represent the mean ± SEM (n = 3) of three independent experiments. c. Densitometric ratio of Erk1/2 to β-tubulin. Sperm treated with 17-AAG (5 µM) had significantly lower Erk1/2 expression than vehicle control (*P < 0.05). Data represent the mean ± SEM (n = 3) of three independent experiments

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