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Fig. 4 | Reproductive Biology and Endocrinology

Fig. 4

From: Expression of tissue factor and tissue factor pathway inhibitors during ovulation in rats: a relevance to the ovarian hyperstimulation syndrome

Fig. 4

Changes in the ovarian gene expression of tissue factor, Tfpi-1, and Tfpi-2, by ovulation-inhibiting agents in vivo. Equine CG-primed immature rats were injected with vehicle (0.1% DMSO for control), progesterone receptor antagonist (RU486, 10 mg/kg), cyclooxygenase inhibitor (Indo; indomethacin, 10 mg/kg), lipoxygenase inhibitor (NDGA; nordihydroguaiaretic acid, 3 mg/kg), or PPARγ antagonist (GW9662, 2 mg/kg) 30 min before hCG administration. Ovaries were collected at 6 h for tissue factor (Tf) and Tfpi-2 and, at 12 h, for Tfpi-1, following hCG treatment for real-time PCR analysis. Data are presented as the mean ± SEM of five independently performed experiments. *, P < 0.05 vs. hCG 6 h or 12 h

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