Fig. 5
From: Effect of edaravone on pregnant mice and their developing fetuses subjected to placental ischemia
Representative photographs of double stained endoskeleton of fetuses and their body parts from different groups. (A) Whole fetus indicating severe loss of ossification in fetuses from RV group (A3). (B) Fetal skull showing well ossified bones in SV and SE groups (B1&2), while only supra-occipital and mandible were ossified in RV group (B3) and its amelioration after edaravone group (B4). (C) sternum and sternabrae ossification showing ossification of 6 segments in SV and SE groups (C1&2), 1st segment in RV group (C3) and first four segments in RE group (C4). (D&E) Well-ossified forelimb and pectoral girdle (D) and hindlimb and pelvic girdle (E) in SV and SE groups (1&2), severe delayed ossification in RV group (3) (asterisk) and amelioration after edaravone injection (4). (F) Ossification of lumbar and sacral vertebrae showing highly ossified centra in SV and SE groups (F1&2), complete loss of ossification in RV group (F3), except small portion in the ilium (asterisk), moderate amelioration after edaravone injection (F4). At, atlas; Cl, clavicle; ExO, exoccipital; Fr, frontal; Fe, femur; Fi, fibula; H, humerus; Il, Ilium; IP, interparietal; Is, ischium; Mc, metacarpus; Ma, mandible; Mt, metatarsus; Mx, maxilla; Na, nasal; O, orbit; P, parietal; Ph, phalanges; Pu, pubis; R, radius; Sc, scapula; So, supraoccipital; Sq, squamosal; Ta, tarsus; T, tibia; U, ulna