Table 5 Topology table for up and down regulated genes

Up

SAA1

315

0.10107

69407430

0.321603

Up

ADCY6

312

0.072777

44726506

0.302897

Up

POLR2K

236

0.037471

28379862

0.302013

Up

RPS15

212

0.008152

26431684

0.308863

Up

RPS15A

211

0.007809

26602340

0.309741

Up

RPS5

209

0.007859

26492428

0.309463

Up

RPL13A

207

0.007846

22124842

0.309533

Up

RPS23

205

0.005989

23951504

0.308794

Up

RPLP0

205

0.00818

22450450

0.310438

Up

RPL35

203

0.006165

21837168

0.309417

Up

RPS20

202

0.005559

24073032

0.308564

Up

RPS29

198

0.004498

20672292

0.308426

Up

RBX1

197

0.044386

26711280

0.318217

Up

POLR2J

192

0.020679

20252592

0.293659

Up

RPL30

187

0.006891

19563996

0.308265

Up

RPS8

177

0.004042

18164736

0.30678

Up

RPL35A

174

0.003759

16445648

0.30783

Up

RPS24

174

0.003192

15939464

0.304838

Up

RPL24

173

0.003533

16772430

0.306803

Up

C3AR1

172

0.003177

5121210

0.274955

Up

RPL34

172

0.004039

16061864

0.30719

Up

RPL29

171

0.00494

18453558

0.307647

Up

RPS21

170

0.002685

15196960

0.304636

Up

SNRPD2

168

0.03814

33998368

0.309486

Up

RPS10

164

0.002949

14807414

0.306055

Up

RPL14

163

0.00328

15070824

0.306826

Up

RPL27

160

0.002277

14404254

0.305716

Up

PSMC5

145

0.016771

20051716

0.327066

Up

PSMD14

138

0.008797

20693344

0.312311

Up

RBBP7

136

0.039699

19307334

0.314733

Up

PSMD3

132

0.006138

19507196

0.312264

Up

SRSF6

130

0.01551

18603044

0.305242

Up

PSMB4

128

0.006024

19460760

0.31217

Up

PSMB1

126

0.005935

19159108

0.312736

Up

PSMD10

125

0.006564

19293068

0.313162

Up

PSMB7

121

0.004879

18406276

0.311911

Up

CDC27

121

0.014082

17205180

0.314709

Up

PLCG2

119

0.031441

10514426

0.284595

Up

UBE2E1

111

0.01698

18575766

0.315597

Up

MRPL24

111

0.004006

3985902

0.27419

Up

SEC11A

107

0.005316

8457436

0.302168

Up

EIF3E

105

0.00271

6755804

0.298099

Up

EIF1AX

105

0.00175

6248608

0.298099

Up

ETF1

104

0.003209

7817310

0.300348

Up

SF3B5

104

0.003133

6307886

0.271298

Up

EIF5

103

0.002157

5951468

0.298056

Up

MRPS12

103

0.001566

3803642

0.27381

Up

RPS27L

103

0.003987

8037762

0.3043

Up

RBMX

102

0.006533

8629778

0.302543

Up

SF3B6

101

0.007747

10034416

0.30272

Up

RPL36A

101

0.001189

3109720

0.271102

Up

RSL24D1

100

0.010421

6175826

0.267684

Up

ANAPC5

100

0.005802

14180882

0.312854

Up

ITGAV

98

0.047765

36204220

0.313518

Up

SRP72

98

0.001539

6042806

0.299696

Up

NME2

94

0.034644

15645818

0.312029

Up

YWHAH

93

0.030402

22230232

0.316369

Up

MRPS15

86

0.001926

2385992

0.260394

Up

UQCRQ

83

0.003421

1615130

0.240866

Up

CCNC

83

0.010303

8511008

0.281231

Up

UQCRC1

82

0.02328

14231790

0.289875

Up

MED4

80

0.018252

17775072

0.301683

Up

UQCRFS1

78

0.001699

1157234

0.244233

Up

CCND2

77

0.023553

14830028

0.314399

Up

MRPL12

77

0.002782

2194820

0.259789

Up

POLR1D

75

0.0061

4678140

0.274081

Up

UQCRH

72

0.001221

959168

0.244147

Up

KLHL12

68

0.003828

3608276

0.303719

Up

SLC9A3R1

63

0.021981

10906810

0.303987

Up

XRCC5

63

0.016826

12450448

0.298895

Up

EIF6

62

0.005109

3166876

0.251672

Up

GTF3A

61

0.016181

6249890

0.308426

Up

MRPS6

60

6.26E-04

932952

0.249563

Up

PLA2G2A

59

0.016536

3353206

0.267442

Up

NDUFC2

58

0.009137

6243750

0.288562

Up

TAF7

58

0.008456

6200048

0.248053

Up

NDUFA13

58

0.010438

6851160

0.289086

Up

TSG101

57

0.016521

11031600

0.306145

Up

SAP18

57

0.012307

5315482

0.302256

Up

NDUFS4

56

0.001242

656204

0.239889

Up

SMAD5

56

0.020424

14462992

0.296201

Up

RSL1D1

56

0.011475

16770568

0.229134

Up

NDUFA2

54

7.42E-04

556554

0.239861

Up

NBN

54

0.015436

11207188

0.30323

Up

NEDD8

53

0.011483

3600034

0.320831

Up

PRMT1

52

0.012592

15575898

0.301332

Up

MORF4L1

51

0.010667

4279006

0.296795

Up

CUL4A

50

0.007675

2678820

0.299544

Up

LAMA2

49

0.007709

8570206

0.278844

Up

COX6A1

48

0.001525

801088

0.240334

Up

AK1

46

0.003174

1615960

0.250894

Up

COX5B

42

0.001215

595708

0.239861

Up

TADA3

40

0.010349

2368830

0.281307

Up

SUMO3

40

0.011044

5466788

0.300348

Up

CDKN2B

36

0.006521

2033654

0.280983

Up

SERPINH1

36

0.01212

7196482

0.29909

Up

MRPL20

34

0.002069

1471944

0.293201

Up

COMT

34

0.015004

4152910

0.286109

Up

LSM4

34

0.007332

2056240

0.254456

Up

EXOC5

33

0.00443

1785404

0.263041

Up

SYVN1

32

0.012143

5434366

0.291078

Up

BAK1

31

0.006508

1183542

0.267425

Up

RAB10

30

0.008921

6109230

0.296328

Up

PFDN5

29

0.010966

3969486

0.290567

Up

SCARB1

28

0.010079

5204710

0.299544

Up

COX6C

27

4.36E-04

219006

0.232011

Up

COX4I1

26

6.32E-04

186792

0.232493

Up

EZH1

26

0.001591

543666

0.245377

Up

SUCLG1

26

0.008369

8540110

0.200727

Up

OXCT1

25

0.007475

2818178

0.199778

Up

PHB

24

0.005122

2747910

0.293388

Up

BANF1

20

0.005143

1975740

0.295651

Up

BCCIP

20

0.003654

1838164

0.269444

Up

RDX

18

0.004798

4656272

0.29563

Up

CFL2

15

0.005519

1602836

0.286624

Up

ARF5

12

0.004972

1234824

0.284419

Up

UCHL1

12

0.001629

954606

0.29618

Up

PFN2

11

0.003745

1598036

0.28734

Up

NDUFB2

8

0

0

0.225404

Up

COX6B1

8

0

0

0.225073

Up

COX7A2L

8

0

0

0.225073

Up

COX7C

8

0

0

0.225073

Up

PRPF31

8

1.73E-04

119394

0.213127

Up

COX8A

8

0

0

0.225073

Up

NDUFS5

8

0

0

0.225404

Up

PHB2

8

0.001363

712242

0.308449

Up

ETFB

4

0

0

0.224963

Up

NELFB

3

2.95E-04

570978

0.27419

Up

CKS1B

3

6.28E-06

1544

0.254284

Up

ANAPC13

3

0

0

0.245741

Up

GTF2A2

3

0

0

0.236342

Up

POLE4

3

2.39E-04

114402

0.254863

Up

TYROBP

2

0

0

0.248948

Up

DCAF6

2

0

0

0.241724

Up

SKIL

2

0

0

0.239764

Up

S100A16

2

0

0

0.172622

Up

HMGCL

2

0

0

0.172622

Up

ARHGAP12

2

7.30E-07

10130

0.210056

Up

STX10

2

0

0

0.222748

Up

UQCR11

2

0

0

0.194129

Up

GADD45B

1

0

0

0.188748

Up

PFDN1

1

0

0

0.225159

Up

CDIPT

1

0

0

0.221556

Up

TOMM7

1

0

0

0.211009

Up

MRPS24

1

0

0

0.206607

Up

SBDS

1

0

0

0.201078

Up

COPS7A

1

0

0

0.230512

Up

DERL2

1

0

0

0.225466

Up

DTYMK

1

0

0

0.237835

Up

NDFIP1

1

0

0

0.237726

Up

BTF3L4

1

0

0

0.213292

Up

AFAP1L1

1

0

0

0.195053

Up

ATP6V1D

1

0

0

0.235992

Up

LSM3

1

0

0

0.202852

Up

ARFIP2

1

0

0

0.22145

Up

F13A1

1

0

0

0.201558

Up

ABI3BP

1

0

0

0.18668

Up

NDUFAF3

1

0

0

0.193485

Up

APOD

1

0

0

0.201401

Up

UBL5

1

0

0

0.242915

Up

MFAP5

1

0

0

0.160727

Up

RAB4A

1

0

0

0.234402

Up

SNAPIN

1

0

0

0.232493

Up

UROS

1

0

0

0.212264

Up

PLTP

1

0

0

0.201401

Up

VPS28

1

0

0

0.234402

Up

EIF3L

1

0

0

0.229656

Up

NUDT16

1

0

0

0.237835

Up

BLOC1S1

1

0

0

0.256919

Down

ESR1

250

0.13227

1.07E+08

0.34572

Down

LCK

209

0.099202

95979964

0.328259

Down

S1PR5

174

0.006652

8092966

0.28169

Down

CCL28

174

0.003314

5208440

0.274992

Down

CTNND1

106

0.042469

42968374

0.310275

Down

KNTC1

101

0.02909

80024314

0.25565

Down

NGFR

100

0.036602

63182380

0.318388

Down

TIAM2

95

0.021154

62011932

0.265317

Down

OBSCN

86

0.010365

36096562

0.247534

Down

PLD1

73

0.033394

17246708

0.30421

Down

CALCR

71

0.002592

2172836

0.25466

Down

PTGDR

70

0.002067

1966748

0.255524

Down

FASLG

69

0.019813

7248566

0.301244

Down

NEDD4L

68

0.023391

18526624

0.311841

Down

GLI3

68

0.017183

7308126

0.2879

Down

CEP135

65

0.013666

21907982

0.267857

Down

SDCCAG8

65

0.013666

21907982

0.267857

Down

ARHGAP39

61

0.006186

28702190

0.252655

Down

TNKS

60

0.004206

3754360

0.297842

Down

CHEK2

60

0.016237

7288936

0.307601

Down

GLI2

58

0.012509

5073890

0.282922

Down

ENTPD5

57

0.005964

2743528

0.250015

Down

FAM13B

56

0.004818

23506158

0.251122

Down

ARHGAP22

56

0.004818

23506158

0.251122

Down

LAMA5

52

0.00723

12112106

0.258896

Down

SYNJ2

52

0.010084

13175450

0.253879

Down

BCL2L11

52

0.016836

10636772

0.313969

Down

ALOX15

49

0.008753

5227944

0.244161

Down

FGFR3

49

0.011331

25238840

0.255587

Down

GEMIN5

47

0.001525

2623902

0.254973

Down

FAS

47

0.009545

4674560

0.293347

Down

PDE4B

46

0.005717

3857072

0.252024

Down

KCNC1

45

0.011352

17732982

0.215233

Down

TAF4B

45

0.004747

2685668

0.266101

Down

TOP3A

45

0.011616

46078906

0.231272

Down

TTF1

43

0.001327

799808

0.270889

Down

KCNQ4

42

0.027528

31515762

0.226874

Down

MUC17

42

0.019711

25257640

0.157086

Down

NTN1

40

0.012007

10110832

0.266152

Down

COL8A1

38

0.013121

17046748

0.212558

Down

MMRN1

38

0.011827

11815884

0.252424

Down

EPHA4

38

0.003668

1364992

0.273358

Down

MEN1

35

0.006804

6211974

0.272297

Down

GOSR1

34

0.008526

3939382

0.285714

Down

SKA1

32

0.002897

9913724

0.243129

Down

VTI1A

31

0.007925

4181998

0.286386

Down

SYNE2

30

0.007519

9249888

0.228212

Down

ITIH4

26

0.007262

1264158

0.272297

Down

LCAT

26

0.005782

971078

0.252178

Down

TRIB3

24

0.002492

6242350

0.248261

Down

TRAF5

24

0.00684

5476244

0.212395

Down

DNAH3

24

0.007222

8565654

0.215524

Down

PFAS

24

0.014988

8957870

0.288321

Down

SNPH

24

0.00801

15545944

0.224536

Down

GADD45G

20

0.003326

13947820

0.23265

Down

SFRP5

20

0.006774

5015824

0.211927

Down

SPTB

20

0.0063

11636704

0.233978

Down

KAT7

18

0.003392

3121342

0.235683

Down

EPHB4

18

0.001434

905566

0.260034

Down

DNAH5

17

0.002849

3119232

0.205745

Down

HIVEP1

17

0.005211

11367638

0.232859

Down

DNAJC18

16

0.004758

4513144

0.228489

Down

SCNN1D

16

0.001683

759732

0.291057

Down

ZBP1

16

0.0032

6672792

0.233555

Down

RAP1GAP2

15

0.003133

3581154

0.225872

Down

SARDH

15

0.005309

5233702

0.183926

Down

PRPS2

15

0.006081

1607396

0.285281

Down

MYO10

15

0.004221

1310316

0.235723

Down

ABCB4

14

5.59E-04

1308566

0.227248

Down

SPN

13

0.003074

2890384

0.244522

Down

ERO1A

13

0.004612

1425588

0.287161

Down

LPXN

13

0.002728

4156340

0.242304

Down

CD82

12

0.001605

269660

0.279107

Down

CFP

12

0.004063

2388686

0.220588

Down

CDC20B

12

7.24E-04

204270

0.243429

Down

EREG

11

0.00292

4060738

0.221568

Down

GABRA4

11

0.004826

844010

0.188362

Down

STK36

10

5.16E-06

1410

0.231582

Down

CLDN1

10

0.002949

1746194

0.196311

Down

SCAF4

10

0.003013

2202372

0.198039

Down

MFAP3

9

0.003861

3290616

0.191498

Down

PPT2

9

0.003141

1767236

0.210548

Down

NPHP4

9

0.003191

1398268

0.215199

Down

ABI3

8

0.001847

2267982

0.229515

Down

BATF3

8

6.07E-04

393104

0.226291

Down

KLC2

8

0.00245

1875364

0.222485

Down

GRK4

8

5.59E-04

417560

0.222533

Down

ARNTL2

7

0.001968

1639758

0.209684

Down

PPP1R3B

7

0.002897

1494078

0.211732

Down

IFT122

7

0.001127

614274

0.187492

Down

AHSP

7

0.002414

2877402

0.186226

Down

ASIC3

7

0.001895

501964

0.235361

Down

WDR19

7

0.001287

982818

0.187492

Down

MGAM

7

0.002455

406020

0.181388

Down

STXBP5

6

0.00108

832104

0.196993

Down

SLC30A7

6

0.002041

1162028

0.211776

Down

NRL

6

0.001496

1056416

0.226267

Down

KCNMB4

5

0.001932

644596

0.189223

Down

SPAST

5

0.001932

3015012

0.17458

Down

MTF1

5

8.87E-04

1194192

0.226862

Down

FOXP2

5

0.001059

361276

0.219804

Down

IWS1

4

4.91E-04

486888

0.21999

Down

LRSAM1

4

4.66E-04

327264

0.292456

Down

ECD

4

3.00E-08

6

0.246517

Down

RFX3

3

9.66E-04

260498

0.235696

Down

IPP

3

4.83E-04

255296

0.199412

Down

ERG

3

0.001157

1993680

0.288401

Down

SLC9A7

2

4.83E-04

102030

0.189205

Down

KBTBD7

2

4.83E-04

116108

0.284029

Down

CARD14

2

2.67E-05

3564

0.219501

Down

ANKRD6

2

3.60E-07

366

0.212744

Down

ZFYVE1

2

4.83E-04

123952

0.234428

Down

LNX2

1

0

0

0.215132

Down

ATL1

1

0

0

0.148637

Down

LMO7

1

0

0

0.195467