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Table 5 Topology table for up and down regulated genes

From: Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules

Regulation Node Degree Betweenness Stress Closeness
Up SAA1 315 0.10107 69407430 0.321603
Up ADCY6 312 0.072777 44726506 0.302897
Up POLR2K 236 0.037471 28379862 0.302013
Up RPS15 212 0.008152 26431684 0.308863
Up RPS15A 211 0.007809 26602340 0.309741
Up RPS5 209 0.007859 26492428 0.309463
Up RPL13A 207 0.007846 22124842 0.309533
Up RPS23 205 0.005989 23951504 0.308794
Up RPLP0 205 0.00818 22450450 0.310438
Up RPL35 203 0.006165 21837168 0.309417
Up RPS20 202 0.005559 24073032 0.308564
Up RPS29 198 0.004498 20672292 0.308426
Up RBX1 197 0.044386 26711280 0.318217
Up POLR2J 192 0.020679 20252592 0.293659
Up RPL30 187 0.006891 19563996 0.308265
Up RPS8 177 0.004042 18164736 0.30678
Up RPL35A 174 0.003759 16445648 0.30783
Up RPS24 174 0.003192 15939464 0.304838
Up RPL24 173 0.003533 16772430 0.306803
Up C3AR1 172 0.003177 5121210 0.274955
Up RPL34 172 0.004039 16061864 0.30719
Up RPL29 171 0.00494 18453558 0.307647
Up RPS21 170 0.002685 15196960 0.304636
Up SNRPD2 168 0.03814 33998368 0.309486
Up RPS10 164 0.002949 14807414 0.306055
Up RPL14 163 0.00328 15070824 0.306826
Up RPL27 160 0.002277 14404254 0.305716
Up PSMC5 145 0.016771 20051716 0.327066
Up PSMD14 138 0.008797 20693344 0.312311
Up RBBP7 136 0.039699 19307334 0.314733
Up PSMD3 132 0.006138 19507196 0.312264
Up SRSF6 130 0.01551 18603044 0.305242
Up PSMB4 128 0.006024 19460760 0.31217
Up PSMB1 126 0.005935 19159108 0.312736
Up PSMD10 125 0.006564 19293068 0.313162
Up PSMB7 121 0.004879 18406276 0.311911
Up CDC27 121 0.014082 17205180 0.314709
Up PLCG2 119 0.031441 10514426 0.284595
Up UBE2E1 111 0.01698 18575766 0.315597
Up MRPL24 111 0.004006 3985902 0.27419
Up SEC11A 107 0.005316 8457436 0.302168
Up EIF3E 105 0.00271 6755804 0.298099
Up EIF1AX 105 0.00175 6248608 0.298099
Up ETF1 104 0.003209 7817310 0.300348
Up SF3B5 104 0.003133 6307886 0.271298
Up EIF5 103 0.002157 5951468 0.298056
Up MRPS12 103 0.001566 3803642 0.27381
Up RPS27L 103 0.003987 8037762 0.3043
Up RBMX 102 0.006533 8629778 0.302543
Up SF3B6 101 0.007747 10034416 0.30272
Up RPL36A 101 0.001189 3109720 0.271102
Up RSL24D1 100 0.010421 6175826 0.267684
Up ANAPC5 100 0.005802 14180882 0.312854
Up ITGAV 98 0.047765 36204220 0.313518
Up SRP72 98 0.001539 6042806 0.299696
Up NME2 94 0.034644 15645818 0.312029
Up YWHAH 93 0.030402 22230232 0.316369
Up MRPS15 86 0.001926 2385992 0.260394
Up UQCRQ 83 0.003421 1615130 0.240866
Up CCNC 83 0.010303 8511008 0.281231
Up UQCRC1 82 0.02328 14231790 0.289875
Up MED4 80 0.018252 17775072 0.301683
Up UQCRFS1 78 0.001699 1157234 0.244233
Up CCND2 77 0.023553 14830028 0.314399
Up MRPL12 77 0.002782 2194820 0.259789
Up POLR1D 75 0.0061 4678140 0.274081
Up UQCRH 72 0.001221 959168 0.244147
Up KLHL12 68 0.003828 3608276 0.303719
Up SLC9A3R1 63 0.021981 10906810 0.303987
Up XRCC5 63 0.016826 12450448 0.298895
Up EIF6 62 0.005109 3166876 0.251672
Up GTF3A 61 0.016181 6249890 0.308426
Up MRPS6 60 6.26E-04 932952 0.249563
Up PLA2G2A 59 0.016536 3353206 0.267442
Up NDUFC2 58 0.009137 6243750 0.288562
Up TAF7 58 0.008456 6200048 0.248053
Up NDUFA13 58 0.010438 6851160 0.289086
Up TSG101 57 0.016521 11031600 0.306145
Up SAP18 57 0.012307 5315482 0.302256
Up NDUFS4 56 0.001242 656204 0.239889
Up SMAD5 56 0.020424 14462992 0.296201
Up RSL1D1 56 0.011475 16770568 0.229134
Up NDUFA2 54 7.42E-04 556554 0.239861
Up NBN 54 0.015436 11207188 0.30323
Up NEDD8 53 0.011483 3600034 0.320831
Up PRMT1 52 0.012592 15575898 0.301332
Up MORF4L1 51 0.010667 4279006 0.296795
Up CUL4A 50 0.007675 2678820 0.299544
Up LAMA2 49 0.007709 8570206 0.278844
Up COX6A1 48 0.001525 801088 0.240334
Up AK1 46 0.003174 1615960 0.250894
Up COX5B 42 0.001215 595708 0.239861
Up TADA3 40 0.010349 2368830 0.281307
Up SUMO3 40 0.011044 5466788 0.300348
Up CDKN2B 36 0.006521 2033654 0.280983
Up SERPINH1 36 0.01212 7196482 0.29909
Up MRPL20 34 0.002069 1471944 0.293201
Up COMT 34 0.015004 4152910 0.286109
Up LSM4 34 0.007332 2056240 0.254456
Up EXOC5 33 0.00443 1785404 0.263041
Up SYVN1 32 0.012143 5434366 0.291078
Up BAK1 31 0.006508 1183542 0.267425
Up RAB10 30 0.008921 6109230 0.296328
Up PFDN5 29 0.010966 3969486 0.290567
Up SCARB1 28 0.010079 5204710 0.299544
Up COX6C 27 4.36E-04 219006 0.232011
Up COX4I1 26 6.32E-04 186792 0.232493
Up EZH1 26 0.001591 543666 0.245377
Up SUCLG1 26 0.008369 8540110 0.200727
Up OXCT1 25 0.007475 2818178 0.199778
Up PHB 24 0.005122 2747910 0.293388
Up BANF1 20 0.005143 1975740 0.295651
Up BCCIP 20 0.003654 1838164 0.269444
Up RDX 18 0.004798 4656272 0.29563
Up CFL2 15 0.005519 1602836 0.286624
Up ARF5 12 0.004972 1234824 0.284419
Up UCHL1 12 0.001629 954606 0.29618
Up PFN2 11 0.003745 1598036 0.28734
Up NDUFB2 8 0 0 0.225404
Up COX6B1 8 0 0 0.225073
Up COX7A2L 8 0 0 0.225073
Up COX7C 8 0 0 0.225073
Up PRPF31 8 1.73E-04 119394 0.213127
Up COX8A 8 0 0 0.225073
Up NDUFS5 8 0 0 0.225404
Up PHB2 8 0.001363 712242 0.308449
Up ETFB 4 0 0 0.224963
Up NELFB 3 2.95E-04 570978 0.27419
Up CKS1B 3 6.28E-06 1544 0.254284
Up ANAPC13 3 0 0 0.245741
Up GTF2A2 3 0 0 0.236342
Up POLE4 3 2.39E-04 114402 0.254863
Up TYROBP 2 0 0 0.248948
Up DCAF6 2 0 0 0.241724
Up SKIL 2 0 0 0.239764
Up S100A16 2 0 0 0.172622
Up HMGCL 2 0 0 0.172622
Up ARHGAP12 2 7.30E-07 10130 0.210056
Up STX10 2 0 0 0.222748
Up UQCR11 2 0 0 0.194129
Up GADD45B 1 0 0 0.188748
Up PFDN1 1 0 0 0.225159
Up CDIPT 1 0 0 0.221556
Up TOMM7 1 0 0 0.211009
Up MRPS24 1 0 0 0.206607
Up SBDS 1 0 0 0.201078
Up COPS7A 1 0 0 0.230512
Up DERL2 1 0 0 0.225466
Up DTYMK 1 0 0 0.237835
Up NDFIP1 1 0 0 0.237726
Up BTF3L4 1 0 0 0.213292
Up AFAP1L1 1 0 0 0.195053
Up ATP6V1D 1 0 0 0.235992
Up LSM3 1 0 0 0.202852
Up ARFIP2 1 0 0 0.22145
Up F13A1 1 0 0 0.201558
Up ABI3BP 1 0 0 0.18668
Up NDUFAF3 1 0 0 0.193485
Up APOD 1 0 0 0.201401
Up UBL5 1 0 0 0.242915
Up MFAP5 1 0 0 0.160727
Up RAB4A 1 0 0 0.234402
Up SNAPIN 1 0 0 0.232493
Up UROS 1 0 0 0.212264
Up PLTP 1 0 0 0.201401
Up VPS28 1 0 0 0.234402
Up EIF3L 1 0 0 0.229656
Up NUDT16 1 0 0 0.237835
Up BLOC1S1 1 0 0 0.256919
Down ESR1 250 0.13227 1.07E+08 0.34572
Down LCK 209 0.099202 95979964 0.328259
Down S1PR5 174 0.006652 8092966 0.28169
Down CCL28 174 0.003314 5208440 0.274992
Down CTNND1 106 0.042469 42968374 0.310275
Down KNTC1 101 0.02909 80024314 0.25565
Down NGFR 100 0.036602 63182380 0.318388
Down TIAM2 95 0.021154 62011932 0.265317
Down OBSCN 86 0.010365 36096562 0.247534
Down PLD1 73 0.033394 17246708 0.30421
Down CALCR 71 0.002592 2172836 0.25466
Down PTGDR 70 0.002067 1966748 0.255524
Down FASLG 69 0.019813 7248566 0.301244
Down NEDD4L 68 0.023391 18526624 0.311841
Down GLI3 68 0.017183 7308126 0.2879
Down CEP135 65 0.013666 21907982 0.267857
Down SDCCAG8 65 0.013666 21907982 0.267857
Down ARHGAP39 61 0.006186 28702190 0.252655
Down TNKS 60 0.004206 3754360 0.297842
Down CHEK2 60 0.016237 7288936 0.307601
Down GLI2 58 0.012509 5073890 0.282922
Down ENTPD5 57 0.005964 2743528 0.250015
Down FAM13B 56 0.004818 23506158 0.251122
Down ARHGAP22 56 0.004818 23506158 0.251122
Down LAMA5 52 0.00723 12112106 0.258896
Down SYNJ2 52 0.010084 13175450 0.253879
Down BCL2L11 52 0.016836 10636772 0.313969
Down ALOX15 49 0.008753 5227944 0.244161
Down FGFR3 49 0.011331 25238840 0.255587
Down GEMIN5 47 0.001525 2623902 0.254973
Down FAS 47 0.009545 4674560 0.293347
Down PDE4B 46 0.005717 3857072 0.252024
Down KCNC1 45 0.011352 17732982 0.215233
Down TAF4B 45 0.004747 2685668 0.266101
Down TOP3A 45 0.011616 46078906 0.231272
Down TTF1 43 0.001327 799808 0.270889
Down KCNQ4 42 0.027528 31515762 0.226874
Down MUC17 42 0.019711 25257640 0.157086
Down NTN1 40 0.012007 10110832 0.266152
Down COL8A1 38 0.013121 17046748 0.212558
Down MMRN1 38 0.011827 11815884 0.252424
Down EPHA4 38 0.003668 1364992 0.273358
Down MEN1 35 0.006804 6211974 0.272297
Down GOSR1 34 0.008526 3939382 0.285714
Down SKA1 32 0.002897 9913724 0.243129
Down VTI1A 31 0.007925 4181998 0.286386
Down SYNE2 30 0.007519 9249888 0.228212
Down ITIH4 26 0.007262 1264158 0.272297
Down LCAT 26 0.005782 971078 0.252178
Down TRIB3 24 0.002492 6242350 0.248261
Down TRAF5 24 0.00684 5476244 0.212395
Down DNAH3 24 0.007222 8565654 0.215524
Down PFAS 24 0.014988 8957870 0.288321
Down SNPH 24 0.00801 15545944 0.224536
Down GADD45G 20 0.003326 13947820 0.23265
Down SFRP5 20 0.006774 5015824 0.211927
Down SPTB 20 0.0063 11636704 0.233978
Down KAT7 18 0.003392 3121342 0.235683
Down EPHB4 18 0.001434 905566 0.260034
Down DNAH5 17 0.002849 3119232 0.205745
Down HIVEP1 17 0.005211 11367638 0.232859
Down DNAJC18 16 0.004758 4513144 0.228489
Down SCNN1D 16 0.001683 759732 0.291057
Down ZBP1 16 0.0032 6672792 0.233555
Down RAP1GAP2 15 0.003133 3581154 0.225872
Down SARDH 15 0.005309 5233702 0.183926
Down PRPS2 15 0.006081 1607396 0.285281
Down MYO10 15 0.004221 1310316 0.235723
Down ABCB4 14 5.59E-04 1308566 0.227248
Down SPN 13 0.003074 2890384 0.244522
Down ERO1A 13 0.004612 1425588 0.287161
Down LPXN 13 0.002728 4156340 0.242304
Down CD82 12 0.001605 269660 0.279107
Down CFP 12 0.004063 2388686 0.220588
Down CDC20B 12 7.24E-04 204270 0.243429
Down EREG 11 0.00292 4060738 0.221568
Down GABRA4 11 0.004826 844010 0.188362
Down STK36 10 5.16E-06 1410 0.231582
Down CLDN1 10 0.002949 1746194 0.196311
Down SCAF4 10 0.003013 2202372 0.198039
Down MFAP3 9 0.003861 3290616 0.191498
Down PPT2 9 0.003141 1767236 0.210548
Down NPHP4 9 0.003191 1398268 0.215199
Down ABI3 8 0.001847 2267982 0.229515
Down BATF3 8 6.07E-04 393104 0.226291
Down KLC2 8 0.00245 1875364 0.222485
Down GRK4 8 5.59E-04 417560 0.222533
Down ARNTL2 7 0.001968 1639758 0.209684
Down PPP1R3B 7 0.002897 1494078 0.211732
Down IFT122 7 0.001127 614274 0.187492
Down AHSP 7 0.002414 2877402 0.186226
Down ASIC3 7 0.001895 501964 0.235361
Down WDR19 7 0.001287 982818 0.187492
Down MGAM 7 0.002455 406020 0.181388
Down STXBP5 6 0.00108 832104 0.196993
Down SLC30A7 6 0.002041 1162028 0.211776
Down NRL 6 0.001496 1056416 0.226267
Down KCNMB4 5 0.001932 644596 0.189223
Down SPAST 5 0.001932 3015012 0.17458
Down MTF1 5 8.87E-04 1194192 0.226862
Down FOXP2 5 0.001059 361276 0.219804
Down IWS1 4 4.91E-04 486888 0.21999
Down LRSAM1 4 4.66E-04 327264 0.292456
Down ECD 4 3.00E-08 6 0.246517
Down RFX3 3 9.66E-04 260498 0.235696
Down IPP 3 4.83E-04 255296 0.199412
Down ERG 3 0.001157 1993680 0.288401
Down SLC9A7 2 4.83E-04 102030 0.189205
Down KBTBD7 2 4.83E-04 116108 0.284029
Down CARD14 2 2.67E-05 3564 0.219501
Down ANKRD6 2 3.60E-07 366 0.212744
Down ZFYVE1 2 4.83E-04 123952 0.234428
Down LNX2 1 0 0 0.215132
Down ATL1 1 0 0 0.148637
Down LMO7 1 0 0 0.195467
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