Fig. 7
From: Irisin deletion induces a decrease in growth and fertility in mice
mRNA expression related to reproduction is downregulated in Fndc5 mutant mice. a: The heat map for mRNA analyses of the ovaries, muscle and hypothalamus in WT and Fndc5 mutant mice. b: The downregulated mRNAs in Fndc5 mutant mice are associated with steroid hormone synthesis. c: The different MS/MS spectra of Akr1c18, Mamld1 and Cyp19a1 in Fndc5 mutant and WT mice are shown. d: qRT-PCR results for the ovaries confirmed the decreased expression of Akr1c18, Mamld1 and Cyp19a1 in Fndc5 mutant mice compared with WT mice. (n = 5 biologically independent Fndc5 mutant or WT mice). Data are presented as the mean ± SD; *P < 0.05 compared to WT mice