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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Expanding the mutational spectrum of monogenic hypogonadotropic hypogonadism: novel mutations in ANOS1 and FGFR1 genes

Fig. 2

Mapping of FGFR1 variants to DNA sequence and protein domains. a Schematic presentation of FGFR1 gene, variants’ positions identified in this study are indicated in red. b Results of automated DNA sequencing for FGFR1 mutations in four probands. c Schematic presentations of FGFR-1: IgI, IgII and IgIII: three immunoglobulin-like domains; TM: a transmembrane helix; TK1, TK2: two intracellular domains; positions of the mutations are indicated in red. d UniProt alignment of FGFR-1 regions containing variants identified in this study and amino acid variations across species from zebrafish to human

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