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Fig. 1 | Reproductive Biology and Endocrinology

Fig. 1

From: Expanding the mutational spectrum of monogenic hypogonadotropic hypogonadism: novel mutations in ANOS1 and FGFR1 genes

Fig. 1

Mapping of ANOS1 variants to DNA sequence and protein domains. a Schematic presentation of ANOS1 gene, variants’ positions identified in this study are indicated in red. b Results of automated DNA sequencing for ANOS1 mutations in two probands. c Schematic presentations of anosmin-1 domains. SP: signal peptide; CR: cysteine-rich region; WAP: whey acidic protein –like domain, FNIII: fibronectin type III domain; H: C-terminal region rich in basic histidine and proline residues; positions of the mutations are indicated in red

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