Table 4 The utility of siRNA mediated gene silencing approaches in PCOS research
From: Non-coding RNAs in polycystic ovary syndrome: a systematic review and meta-analysis
Study | Detected in tissue/cell | No. of PCOS and control | Age of PCOS/ control (years) | BMI of PCOS/ control (m/kg2) | siRNA Transfection |
|---|---|---|---|---|---|
Anjali et al. 2015 [101] | Granulosa cells | 18 PCOS vs 30 controls | NA/ NA | NA/ NA | SiRNAs target IRS-2, PI3K, Akt |
Li et al. 2016 [102] | Granulosa cells | 10 PCOS vs 10 controls | NA/ NA | NA/ NA | SiRNAs target heat shock protein 90B1 |
Song et al. 2018 [103] | Granulosa cells | 25 PCOS vs 25 controls | 27.77 ± 4.34/ 29.39 ± 3.37 | 21.24 ± 3.59/22.02 ± 3.30 | SiRNA 439, 1930, and 2117 target human insulin receptor gene |