Table 1 The main roles of CR in uterus, pregnancy and reproductive-related diseases
From: Caloric restriction in female reproduction: is it beneficial or detrimental?
Authors | Year | Species | Aspects | Influence of CR |
|---|---|---|---|---|
Elias et al. [78] | 2007 | Humans | Uterus | CR during puberty relates to irregular menses, and CR during childhood prolongs the time from menarche to regular menses. |
Lumey et al. [79] | 1998 | Humans | Pregnancy | CR in early pregnancy triggers compensatory growth of placenta. |
Roseboom et al. [80] | 2006 | Humans | Pregnancy | Prenatal CR gives lasting negative consequences to offspring’s health, especially in early gestation. |
Harper et al. [81] | 2015 | Mice | Pregnancy | CR during early gestation makes placental alternations reversible, resulting in metabolically normal offspring. |
Harrath et al. [82] | 2017 | Rats | Pregnancy | Female offspring exposed to prenatal CR have an early puberty onset and a short reproductive lifespan. |
Yarde et al. [83] | 2013 | Humans | Pregnancy | No relationship between prenatal CR and reproductive activities of offspring. |
Fenichel et al. [84] | 2007 | Humans | Reproductive-related diseases | CR develops hypothalamic amenorrhea. |
Marzouk et al. [85] | 2015 | Humans | Reproductive-related diseases | CR alleviates the deleterious conditions of PCOS patients with obesity. |
Lope et al. [86] | 2019 | Humans | Reproductive-related diseases | CR reduces the incidence of breast cancer |