Fig. 3
From: Caloric restriction in female reproduction: is it beneficial or detrimental?
The potential mechanism of CR delaying ovary aging in female rodents. This mechanism is divided into two avenues. a One is CR preserving ovarian follicle pool, which is mediated by the SIRT1 activation and IGF-1 inhibition, which still need to be elucidated. b The other one is CR increasing egg quality, which is achieved by activating SIRT3 and inhibiting the occurrence of meiotic spindle and mitochondria disorder. Solid arrow indicates the promotion. Dotted arrow indicates the inhibition