Risk of birth defects in children conceived by artificial oocyte activation and intracytoplasmic sperm injection: a meta-analysis

Table 2 Number of birth defects in specific organ system from included studies

Author(s)	Specific organ system	Circulatory system	Genitourinary system	Musculoskeletal system	Digestive system	Nervous system	Face	Beckwith-Weidemann syndrome	Poland syndrome
Deemeh [18]	AOA	0	0	0	0	0	0	0	0
Deemeh [18]	ICSI	1	0	1	0	0	0	0	0
Miller [15]	AOA^a	4	2	2	0	0	0	1	0
Miller [15]	ICSI^b	8	5	3	2	3	1	0	0
Li B [17]	AOA	2	0	0	0	0	0	0	0
Li B [17]	ICSI	20	1	3	0	0	3	0	1

ICSI intracytoplasmic sperm injection, AOA artificial oocyte activation
^aIn the AOA group, one case with several structural defects (dysplastic kidney, reflux, ventricular septal defect) and another case with ventricular septal defect, interrupted inferior vena cava and short thumb with low insertion of right hand
^bIn the ICSI group, one case with both hypospadias and ventricular septal defect

ISSN: 1477-7827