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Fig. 3 | Reproductive Biology and Endocrinology

Fig. 3

From: Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome

Fig. 3

GH enhanced PI3K/Akt signaling in GCs from patients with PCOS. a The mRNA expression of FOXO1 was significantly lower in GCs of the PCOS-GH group compared with the PCOS-C group (P < 0.05), but similar to those in non-PCOS controls (P > 0.05). *P < 0.05 compared with the PCOS-C group. b B showed the protein bands of p-PI3K, PI3K, p-Akt, Akt and p-FOXO1 and FOXO1 by western blot. GAPDH was used as a protein-loading control. C The protein level of p-PI3K/PI3K, p-Akt/Akt and p-FOXO1 were significantly higher, whereas FOXO1 was significantly lower in GCs of the PCOS-GH group compared with those in the PCOS-C group (P < 0.05), but similar to those in non-PCOS controls (P > 0.05). *P < 0.05 compared with the PCOS-C group

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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