Skip to main content
Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome

Fig. 2

GH improves MMP and inhibits GCs apoptosis in patients with PCOS. a Flow cytometric dot plots showed that the ratios of red/green fluorescence are decreased in the PCOS-C group compared with those in the non-PCOS control and PCOS-GH groups. The ratios of red/green fluorescence were calculated to characterize MMP. b The MMP was significantly higher in the PCOS-GH group than in the PCOS-C group (0.94 ± 0.26 vs. 0.22 ± 0.18), but similar to non-PCOS controls (0.79 ± 0.21) (P > 0.05). *P < 0.05 compared with the PCOS-C group. c Flow cytometric dot plots showed that the numbers of early and late apoptotic cells are increased in the PCOS-C group compared with those in the non-PCOS control and PCOS-GH groups. PI and FITC are the abbreviations of propidium iodide and fluorescein isothiocyanate, respectively. d The early and late apoptotic rates were significantly lower (7.20% vs. 28.18, and 9.37% vs.19.01%, respectively) in the PCOS-GH group than those in the PCOS-C group (P < 0.05), but similar to those in non-PCOS controls (11.07 and 11.48%, respectively) (P > 0.05). *P < 0.05 compared with the PCOS-C group

Back to article page

Reproductive Biology and Endocrinology

ISSN: 1477-7827

Contact us